Volume 21, Issue 1
Heterocyclic Compounds
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ChemInform Abstract: The Chemistry of 2H-3,1-Benzoxazine-2,4(1H)-dione (Isatoic Anhydride). Part 21. A Mild Process for the Application of 10-Alkyl-9-acridanones and Its Application to the Synthesis of Acridone Alkaloids.

G. M. COPPOLA

G. M. COPPOLA

Chem. Res. Dep., Sandoz Pharm. Corp., East Hanover, NJ 07936, USA

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H. F. SCHUSTER

H. F. SCHUSTER

Chem. Res. Dep., Sandoz Pharm. Corp., East Hanover, NJ 07936, USA

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First published: January 2, 1990

Abstract

10-Substituted-9-acridanones such as (IV) are readily prepared by the reaction of the isatoic anhydride (I) with 2-cyclohexenone (II) and subsequent aromatization.

ChemInform Abstract

10-Substituted-9-acridanones such as (IV) are readily prepared by the reaction of the isatoic anhydride (I) with 2-cyclohexenone (II) and subsequent aromatization. Two alkaloids, i.e. 1,2,3-trimethoxy-10-methylacridone (VIIIa) and evoxanthine (VIIIb), are prepared by this method.

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