ChemInform Abstract: An Electrophile-Assisted Nonsolvent Synthesis of Alkyl Macroisocyclic Ethers: An Improved Nonsolvent Williamson Synthesis of Medium-Sized Alkyl Carbocyclic Ethers.
ChemInform Abstract
The macrocyclic alcohols (I) react with the alkyl halides (II) and sodium hydride in the absence of solvents to give the ethers (III).