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ChemInform Abstract: Unsaturated Amino Acids: Synthesis of trans-3,4-Didehydro Analogues of L-Ornithine and L-Arginine.
First published: May 30, 1989
Abstract
The key steps in the synthesis of the unsaturated amino acids (VIII) and (X) are the coupling of the N-acetylaminomalonate (I) with the propiolate (II), forming the trans-configurated acrylate (III), and the Gabriel amination of the chloride (V) with potassium phthalimide (VI).
ChemInform Abstract
The key steps in the synthesis of the unsaturated amino acids (VIII) and (X) are the coupling of the N-acetylaminomalonate (I) with the propiolate (II), forming the trans-configurated acrylate (III), and the Gabriel amination of the chloride (V) with potassium phthalimide (VI). N-Deacetylation is achieved by enzymatic hydrolysis.
