Heterocyclic Compounds
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ChemInform Abstract: Synthesis and Antimicrobial Activities of Some Isoxazolo(5′,4′:4,5)pyrimido(6,1-c)-1,2,4-triazine Derivatives.
First published: January 10, 1989
Abstract
Reaction of the 4-chloroisoxazolopyrimidines (I) with hydrazine hydrate (II) gives the hydrazino derivatives (III) which are coupled with chloroacetone (IV), producing the hydrazones (V).
ChemInform Abstract
Reaction of the 4-chloroisoxazolopyrimidines (I) with hydrazine hydrate (II) gives the hydrazino derivatives (III) which are coupled with chloroacetone (IV), producing the hydrazones (V). These are cyclized in refluxing ethanol, forming the triazines (VI) mentioned in the title. The compounds (V) and (VI) have antibacterial and antifungal activity.
