Heterocyclic Compounds
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ChemInform Abstract: A Novel One-Pot Synthesis of Substituted 4-tert-Butyldimethylsilyloxythiazoles.
First published: January 10, 1989
Abstract
The α-halocarboxylic acid derivatives (I) undergo cyclocondensation with the thioamides (II) in the presence of the silyl chloride (III) and a base, forming the 4-siloxythiazoles (IV).
ChemInform Abstract
The α-halocarboxylic acid derivatives (I) undergo cyclocondensation with the thioamides (II) in the presence of the silyl chloride (III) and a base, forming the 4-siloxythiazoles (IV). Heating of (IVa) or (IVb) with dimethyl acetylenedicarboxylate (V) produces the 2-siloxypyridines (VI) which are desilylated to give (VII).
