Heterocyclic Compounds
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ChemInform Abstract: Asymmetric Synthesis via Acetal Templates. Part 15. The Preparation of Enantiomerically Pure Mevinolin Analogues.
First published: January 10, 1989
ChemInform Abstract
The key step in the synthesis of the chiral δ-lactones (V) is the titanium tetrachloride promoted reaction of the cyclic acetals (I) with the bis(siloxy)methoxybutadiene (II), yielding the δ-alkoxy-β-keto esters (III).
