Heterocyclic Compounds
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ChemInform Abstract: Asymmetric Michael Addition/Lactamization via SAMP-/RAMP-Hydrazones. Enantioselective Synthesis of Substituted Tetrahydro-2,5(1H,3H)-quinolinediones.
First published: January 26, 1988
Abstract
The chiral hydrazine (II) reacts with the cyclohexane-1,3-diones (I) to form the tautomers (III) of the corresponding monohydrazones.
ChemInform Abstract
The chiral hydrazine (II) reacts with the cyclohexane-1,3-diones (I) to form the tautomers (III) of the corresponding monohydrazones. These are coupled with the benzylidenemalonates (IV), yielding the adducts (V). Cyclization and deprotection produce the optically active quinolinediones (VIII).
