Heterocyclic Compounds
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ChemInform Abstract: A Stereoselective Synthesis of cis-4-Acetonyl-1-benzyl-3-ethylpiperidine.
First published: January 26, 1988
Abstract
1-Benzyl-3-ethyl-4-piperidone (III), prepared from the piperidone (I), reacts with diethyl 2-oxo-propylphosphonate (IV) to form a mixture of the unsaturated ketones (V) - (VII).
ChemInform Abstract
1-Benzyl-3-ethyl-4-piperidone (III), prepared from the piperidone (I), reacts with diethyl 2-oxo-propylphosphonate (IV) to form a mixture of the unsaturated ketones (V) - (VII). These are hydrogenated, producing a moderate yield of the 4-acetonyl-1-benzyl-3-ethyl-piperidines (VIII). These are obtained in a better yield from (III) and the triethyl phosphonoacetate (IX) as shown in the reaction scheme. Prolonged reaction of (III) with (IX) gives the tetrahydropyridineacetate (XIV).
