Heterocyclic Compounds
Full Access
ChemInform Abstract: Acrolein as a Synthon for 6-Hydroxytetrahydropyrimidines, 1,4(1,6)-Dihydropyrimidines, and Pyrimidines.
First published: January 12, 1988
Abstract
The amidines (II) are coupled with the aldehydes (I), producing the hydroxytetrahydropyrimidines (III).
ChemInform Abstract
The amidines (II) are coupled with the aldehydes (I), producing the hydroxytetrahydropyrimidines (III). (IIIa) - (IIIc) are dehydrated to form the dihydropyrimidines (IV). Oxidation of (IVc) gives the pyrimidine (V).
