Heterocyclic Compounds
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ChemInform Abstract: Cobalt-Mediated (2 + 2 + 2) Cycloadditions of Alkynes to the Imidazole 4,5 Double Bond. First Synthesis of the 3a,7a-Dihydrobenz-imidazole Nucleus and Its Preliminary Chemistry Including a Novel Quinoline Construction.
First published: January 12, 1988
Abstract
The title addition of the alkynes (II) or (V) to the imidazole (I) regioselectively yields the compounds (IVa) or (VI) as major or sole products.
ChemInform Abstract
The title addition of the alkynes (II) or (V) to the imidazole (I) regioselectively yields the compounds (IVa) or (VI) as major or sole products. The structure of (IVa) is confirmed by X-ray analysis (space group P21/c with Z=4). (VIc) is transformed to the title quinoline derivative (X) via demetalation, aromatization and imine hydrolysis.
