Heterocyclic Compounds
Full Access
ChemInform Abstract: Synthesis of Sterically Hindered 4-Dialkylamino Pyridines.
First published: January 12, 1988
Abstract
The 4-chloropyridine N-oxide (Ia) undergoes substitution with the amines (IIa) and (IId), yielding the 4-amino derivatives (III).
ChemInform Abstract
The 4-chloropyridine N-oxide (Ia) undergoes substitution with the amines (IIa) and (IId), yielding the 4-amino derivatives (III). Analogous reaction of (Ia) and (IIb) is only achieved under more vigorous conditions which cause simultanous deoxygenation, yielding the aminopyridine (IVa). The 4-chloro or 4-nitrotrimethylpyridine N-oxides (Ib) and (Ic) are treated with (II) in a similar manner, producing the aminopyridines (IVb) - (IVd).
