Heterocyclic Compounds
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ChemInform Abstract: Synthesis and Reactivity of Fluorinated Enynes.
First published: January 12, 1988
Abstract
Palladium-catalyzed cross-coupling reaction of the vinylic iodides (I) with the acetylides (II) yields the fluoroenynes (III).
ChemInform Abstract
Palladium-catalyzed cross-coupling reaction of the vinylic iodides (I) with the acetylides (II) yields the fluoroenynes (III). (IIId) and (IIIe) dimerize upon heating to form the cyclobutanes (IV). Treatment of (IIIe) with sulfuric acid leads to the formation of the fluoroallenic acid fluoride (V) and the lactones (VI) and (VII). Acidic hydrolysis of (IIIa) gives the α-fluoro-β-diketones (VIII) and the cyclic α-fluoro enones (IX).
