Heterocyclic Compounds
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ChemInform Abstract: Synthesis and Antifilarial Activity of 5(6)-Phosphoramidobenzimidazole-2-carbamates and 5(6)-Cycloalkylaminophosphonamidobenzimidazole-2-carbamates.
First published: January 12, 1988
Abstract
Since 5(6)-substituted benzimidazole-2-carbamates have been reported to possess excellent antifilarial activity, type (V) which has novel substituents at the 5(6)-position is synthesized.
ChemInform Abstract
Since 5(6)-substituted benzimidazole-2-carbamates have been reported to possess excellent antifilarial activity, type (V) which has novel substituents at the 5(6)-position is synthesized. Pharmacological tests reveal that (Va), (Vb) and (Vd) exhibit positive antifilarial effects. Of these, (Va) is found to be the most active compound, whereas (Vd) is toxic to the host. All other (V) are inactive.
