Preparative Organic Chemistry
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ChemInform Abstract: Hydroformylation of Formaldehyde to give Glycolaldehyde with Halide- Promoted Rh4(CO)12.
First published: January 12, 1988
Abstract
Hydroformylation of paraformaldehyde (I) or 37% aqueous formaldehyde with syngas (II) in the presence of Rh4(CO)12 and bulky onium halides yields glycolaldehyde (III), together with methanol (IV) and methyl formate (V).
ChemInform Abstract
Hydroformylation of paraformaldehyde (I) or 37% aqueous formaldehyde with syngas (II) in the presence of Rh4(CO)12 and bulky onium halides yields glycolaldehyde (III), together with methanol (IV) and methyl formate (V). High-boiling by-products are not observed. The reaction is optimized, and mechanistic aspects are discussed in detail.
