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ChemInform Abstract: Synthesis of Amino Acid Esters by Papain.
First published: September 22, 1987
Abstract
A wide range of N-Boc amino acid esters, such as (I), can be prepared from the corresponding acids and alcohols using papain in a biphasic system.
ChemInform Abstract
A wide range of N-Boc amino acid esters, such as (I), can be prepared from the corresponding acids and alcohols using papain in a biphasic system. When optimal reaction conditions are used, the yields for (Ia) become excellent (70-90%). In the case of the sterically hindered (Ib), however, only low to moderate yields are obtained (22-40%). The methodology allows reactions without protection of theside chain. In dicarboxylic amino acids only the α-carbonyl group is esterified, without racemization.
