Heterocyclic Compounds
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ChemInform Abstract: An Improved Preparation of 1,2,5-Triethyl-3-nitropyrrole. Friedel- Crafts Acylation with 2-Fluorobenzoyl Chloride.
First published: September 22, 1987
ChemInform Abstract
The activated trimethylpyrrole (I) is nitrated using potassium nitrate in concentrated sulfuric acid to produce the nitropyrrole (II) which undergoes Friedel-Crafts acylation with o-fluorobenzoyl chloride (III), yielding the 2-fluorophenyl 4'-nitropyrrol-3'-yl ketone (IV).
