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ChemInform Abstract: Synthesis via Vinyl Sulfones. Part 21. Total Synthesis of d,l-Morphine.
First published: September 1, 1987
Abstract
The key step in the total synthesis of morphine (VI) is the coupling of the phenol (I) with the alcohol (II) under Mitsunobu's conditions.
ChemInform Abstract
The key step in the total synthesis of morphine (VI) is the coupling of the phenol (I) with the alcohol (II) under Mitsunobu's conditions. The resulting ether (III) is transformed into the epimeric compound (IV) which is cyclized with butyllithium to yield (V). Further conversions finally lead to morphine (VI).
