ChemInform Abstract: Asymmetric Synthesis of Methyl α-Alkyl-valinates, -leucinates, and -isoleucinates Using (Cyclohexylidene-Protected) D-Galactodialdehyde as Chiral Auxiliary.

ChemInform Abstract

The Schiff bases (III), formed from the components (I) and (II), are diastereoselectively alkylated to the products (V). Subsequent hydrolysis of (V) leads to the alkylated valinates (VI), leucinates (VII), or isoleucinates (VIII), respectively. An X-ray crystal examination of (VIIb) has been performed (P2₁2₁2₁; Z=4).