Volume 18, Issue 35
Organoelement Compounds
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ChemInform Abstract: An Efficient Synthesis of γ-Amino-β-ketoalkylphosphonates from α-Amino Acids.

P. K. CHAKRAVARTY

P. K. CHAKRAVARTY

New Lead Discovery, Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USA

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P. COMBS

P. COMBS

New Lead Discovery, Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USA

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A. ROTH

A. ROTH

New Lead Discovery, Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USA

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W. J. GREENLEE

W. J. GREENLEE

New Lead Discovery, Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USA

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First published: September 1, 1987

Abstract

The amino acid esters (I) react with the phosphonates (II) to give the ketophosphonates (III) which are split by trimethylsilyl bromide to yield the γ-amino-β-ketophosphonates (IV).

ChemInform Abstract

The amino acid esters (I) react with the phosphonates (II) to give the ketophosphonates (III) which are split by trimethylsilyl bromide to yield the γ-amino-β-ketophosphonates (IV). (IR-, NMR-data).

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