Preparative Organic Chemistry
Full Access
ChemInform Abstract: 1,4-Dehydrobromination of 1-Bromo-1,2,3-butatrienes: An Efficient Synthesis of 1,4-Disubstituted 1,3-Diynes.
First published: September 1, 1987
Abstract
Phenylpropargylic alcohol (I) is brominated to give the tribromo compound (II) which is converted to the phosphonium salt (III).
ChemInform Abstract
Phenylpropargylic alcohol (I) is brominated to give the tribromo compound (II) which is converted to the phosphonium salt (III). Reaction of (III) with the aldehydes (IV) results in the formation of the diynes (V). The bromobutatrienes (VI) are formed as intermediates and can be isolated.
