Volume 17, Issue 2 e2000030
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Front Cover: Noncovalent Spin-Labeling of DNA and RNA Triplexes (C&B 2/2020)

Nilesh Kamble

Nilesh Kamble

Science Institute, University of Iceland, Dunhaga 3, 107 R eykjavik, Iceland

The first two authors contributed equally to this study.

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Manpreet Wolfrum

Manpreet Wolfrum

Institute of Organic Chemistry, University of Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany

The first two authors contributed equally to this study.

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Thomas Halbritter

Thomas Halbritter

Science Institute, University of Iceland, Dunhaga 3, 107 R eykjavik, Iceland

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Snorri T. Sigurdsson

Corresponding Author

Snorri T. Sigurdsson

Science Institute, University of Iceland, Dunhaga 3, 107 R eykjavik, Iceland

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Clemens Richert

Corresponding Author

Clemens Richert

Institute of Organic Chemistry, University of Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany

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First published: 28 January 2020

Graphical Abstract

Front Cover. Designed DNA and RNA triplexes may be spin-labeled using the guanine derivative shown in the upper right-hand corner of the cover graphic. The labeling does not require a covalent bond and is based on Watson-Crick plus Hoogsteen base pairing of the guanine base and unpaired pyrimidines of the triplex. The resulting complexes have dissociation constants in the micromolar range, as reported by Kamble and Wolfrum et al. in their full paper at 10.1002/cbdv.201900676.

2020 VOLUME 17 NO. 2

Front Cover N. Kamble, M. Wolfrum, T. Halbritter, S. T. Sigurdsson, C. Richert, Chem. Biodiversity 2020, 17, e1900676. Noncovalent Spin-Labeling of DNA and RNA Triplexes.

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