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Free Access
Inside Cover: Construction of Quaternary Carbon Center by Catalytic Asymmetric Alkylation of 3-Arylpiperidin-2-ones Under Phase-Transfer Conditions (Angew. Chem. Int. Ed. 6/2020)
First published: 19 December 2019
Graphical Abstract
Phase-transfer catalysis enabled a highly enantioselective synthesis of δ-lactams having a chiral quaternary carbon center at the α-position. In their Communication on page 2211, T. Inukai, T. Kano, and K. Maruoka demonstrate that the 2,2-diarylvinyl group, a novel protecting group and an achiral auxiliary, improved both yield and enantioselectivity of the asymmetric alkylation of 3-arylpiperidin-2-ones.
