Cover Picture
Free Access
Inside Back Cover: Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus (Angew. Chem. Int. Ed. 44/2018)
First published: 17 October 2018
Graphical Abstract
Bacillus anthracis is the etiologic agent of anthrax disease. In their Communication on page 14619 ff., A. Skerra and co-workers report on the construction of a variant human lipocalin by protein design that binds the iron(III)⋅petrobactin complex with high affinity. Scavenging of this specific siderophore abolishes supply with the essential metal ion and thus effectively suppresses bacterial growth. The background depicts colonies of an anthrax vaccination strain on blood agar (with kind permission from Costin Stoica, Regnum Prokaryotae; http://www.tgw1916.net).
