Volume 56, Issue 19 p. 5133
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Cover Picture: 3-Aminodeoxypyranoses in Glycosylation: Diversity-Oriented Synthesis and Assembly in Oligosaccharides (Angew. Chem. Int. Ed. 19/2017)

Prof. Dr. Jing Zeng

Corresponding Author

Prof. Dr. Jing Zeng

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030 China

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Guangfei Sun

Guangfei Sun

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030 China

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Wang Yao

Wang Yao

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030 China

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Yangbin Zhu

Yangbin Zhu

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030 China

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Ruobin Wang

Ruobin Wang

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030 China

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Lei Cai

Lei Cai

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030 China

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Ke Liu

Ke Liu

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030 China

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Qian Zhang

Qian Zhang

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030 China

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Prof. Dr. Xue-Wei Liu

Prof. Dr. Xue-Wei Liu

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore

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Prof. Dr. Qian Wan

Corresponding Author

Prof. Dr. Qian Wan

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030 China

Institute of Brain Research, Huazhong University of Science and Technology, China

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First published: 29 March 2017
Citations: 1

Graphical Abstract

Tetrasaccharides containing different 3-aminosugar components have been assembled by diversity-oriented synthesis and Yu glycosylation reactions. In their Communication on page 5227 ff., J. Zeng, Q. Wan, and co-workers describe a new type of key intermediate that provides access to naturally occurring 3-aminosugars and analogues thereof. These aminosugars were used in glycosylation reactions and should find applications in drug discovery.

Tetrasaccharides containing different 3-aminosugar components have been assembled by diversity-oriented synthesis and Yu glycosylation reactions. In their Communication on page 5227 ff., J. Zeng, Q. Wan, and co-workers describe a new type of key intermediate that provides access to naturally occurring 3-aminosugars and analogues thereof. These aminosugars were used in glycosylation reactions and should find applications in drug discovery.

Huntington's Disease

In their Communication on page 5202 ff. H. A. Lashuel et al. use protein semisynthesis to investigate the effect of lysine acetylation and phosphorylation on the aggregation of mutant huntingtin exon1. While phosphorylation significantly inhibits the aggregation, acetylation has no effect.

Polymers

K. Nomura and co-workers describe in their Communication on page 5288 ff. the synthesis of end-functionalized poly(9,9′-dialkylfluorene vinylene)s by acyclic diene metathesis polymerization and Wittig-type couplings.

Boron Compounds

The twofold 1,2-carboboration of the dimesitylborinium ion with diphenylacetylene to form another isolable borinium ion with an extended π-conjugated system is described by Y. Shoji and co-workers in their Communication on page 5312 ff.

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