Volume 53, Issue 48 p. 12974
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Inside Cover: Catalytic Asymmetric Functionalization of Aromatic CH Bonds by Electrophilic Trapping of Metal-Carbene-Induced Zwitterionic Intermediates (Angew. Chem. Int. Ed. 48/2014)

Shikun Jia

Shikun Jia

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development; Department of Chemistry, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)

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Dr. Dong Xing

Corresponding Author

Dr. Dong Xing

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development; Department of Chemistry, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development; Department of Chemistry, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)Search for more papers by this author
Dan Zhang

Dan Zhang

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development; Department of Chemistry, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)

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Prof. Dr. Wenhao Hu

Corresponding Author

Prof. Dr. Wenhao Hu

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development; Department of Chemistry, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development; Department of Chemistry, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)Search for more papers by this author
First published: 26 September 2014

Graphical Abstract

An asymmetric three-component reaction of N,N-disubstituted anilines, diazo compounds, and imines is catalyzed by RhII and a chiral phosphoric acid and affords α,α-diaryl benzylic quaternary stereocenters. In their Communication on page 13098 ff., W. Hu, D. Xing et al. report this functionalization of aromatic CH bonds with diazo compounds, which they compare with a “magic tea pot” that allows the mixing of three different tea bags into a wonderful tea.

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