Volume 134, Issue 7 e202200575

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Innentitelbild: Ein Designeraußenmembranprotein fördert die Aufnahme von Täuschmolekülen in einen auf Zytochrom P450BM3 beruhenden Ganzzellbiokatalysator (Angew. Chem. 7/2022)

Masayuki Karasawa,

Masayuki Karasawa

orcid.org/0000-0003-0803-999X

Department of Chemistry, Graduate School of Science, Universität Nagoya, Furo-cho, Chikusa-ku, Nagoya, 464-8602 Japan

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Kai Yonemura,

Kai Yonemura

orcid.org/0000-0002-3447-4998

Department of Chemistry, Graduate School of Science, Universität Nagoya, Furo-cho, Chikusa-ku, Nagoya, 464-8602 Japan

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Dr. Joshua Kyle Stanfield,

Dr. Joshua Kyle Stanfield

orcid.org/0000-0002-2428-2036

Department of Chemistry, Graduate School of Science, Universität Nagoya, Furo-cho, Chikusa-ku, Nagoya, 464-8602 Japan

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Dr. Kazuto Suzuki,

Dr. Kazuto Suzuki

orcid.org/0000-0002-7351-3531

Department of Chemistry, Graduate School of Science, Universität Nagoya, Furo-cho, Chikusa-ku, Nagoya, 464-8602 Japan

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Prof. Dr. Osami Shoji,

Corresponding Author

Prof. Dr. Osami Shoji

[email protected]

orcid.org/0000-0003-3522-0065

Department of Chemistry, Graduate School of Science, Universität Nagoya, Furo-cho, Chikusa-ku, Nagoya, 464-8602 Japan

Core Research for Evolutional Science and Technology (Japan), Science and Technology Agency, 5 Sanbancho, Chiyoda-ku, Tokio, 102-0075 Japan

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Masayuki Karasawa,

Masayuki Karasawa

orcid.org/0000-0003-0803-999X

Department of Chemistry, Graduate School of Science, Universität Nagoya, Furo-cho, Chikusa-ku, Nagoya, 464-8602 Japan

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Kai Yonemura,

Kai Yonemura

orcid.org/0000-0002-3447-4998

Department of Chemistry, Graduate School of Science, Universität Nagoya, Furo-cho, Chikusa-ku, Nagoya, 464-8602 Japan

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Dr. Joshua Kyle Stanfield,

Dr. Joshua Kyle Stanfield

orcid.org/0000-0002-2428-2036

Department of Chemistry, Graduate School of Science, Universität Nagoya, Furo-cho, Chikusa-ku, Nagoya, 464-8602 Japan

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Dr. Kazuto Suzuki,

Dr. Kazuto Suzuki

orcid.org/0000-0002-7351-3531

Department of Chemistry, Graduate School of Science, Universität Nagoya, Furo-cho, Chikusa-ku, Nagoya, 464-8602 Japan

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Prof. Dr. Osami Shoji,

Corresponding Author

Prof. Dr. Osami Shoji

[email protected]

orcid.org/0000-0003-3522-0065

Department of Chemistry, Graduate School of Science, Universität Nagoya, Furo-cho, Chikusa-ku, Nagoya, 464-8602 Japan

Core Research for Evolutional Science and Technology (Japan), Science and Technology Agency, 5 Sanbancho, Chiyoda-ku, Tokio, 102-0075 Japan

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First published: 27 January 2022

https://doi.org/10.1002/ange.202200575

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Graphical Abstract

Eine Schleifendeletionsmutante des Außenmembranproteins F (OmpF) wurde entwickelt, welche die Zellaufnahme von Täuschmolekülen in Escherichia coli fördert. In ihrer Zuschrift (e202111612) berichten Osami Shoji et al., dass die Koexpression der OmpF-Mutante mit Wildtyp-ZYP102A1 einen auf E. coli beruhenden Ganzzellbiokatalysator in die Lage versetzt, Benzol, Alkyl- und Cycloalkylbenzole mithilfe von Täuschmolekülen effizient zu oxidieren, was dieses System seiner praktischen Anwendung einen wichtigen Schritt näher bringt.