Vascular Growth and Remodeling
J.D. Humphrey,
J.D. Humphrey
Texas A&M University, Professor of Biomedical Engineering, College Station, College Station, Texas
Search for more papers by this authorJ.D. Humphrey,
J.D. Humphrey
Texas A&M University, Professor of Biomedical Engineering, College Station, College Station, Texas
Search for more papers by this authorAbstract
The goal of this brief review is to highlight the basic structure and function of large blood vessels, to discuss the homeostatic mechanical environment, and to compare five examples of mechanically induced vascular growth and remodeling. By growth, we mean an increase in mass that is achieved locally via an increase in the number or size of cells and/or via a synthesis of extracellular matrix that exceeds removal. Atrophy, then, can be thought of as negative growth. By remodeling, we mean a change in structure that is achieved by reorganizing existing constituents or by synthesizing new constituents that have a different organization. If we track local turnover of material, as we should, growth and remodeling are seen to typically occur hand in hand, and thus should be considered together. It is hoped that this review stimulates the reader's interest in vascular mechanics and mechanobiology, a field of study with great promise to contribute to improving health care delivery.
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