Insulin-related metabolism following hematopoietic stem cell transplantation in childhood

Corresponding Author

Ronit Elhasid

Department of Pediatric Hemato-Oncology, Rambam Health Care Campus, Haifa, Israel

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Dr Ronit Elhasid
Department of Pediatric Hemato-Oncology
Rambam Health Care Campus
PO Box 9602
Haifa 31096
Israel.
Tel: +972 4 854 2062;
Fax: +972 4 854 2007;
e-mail: [email protected]Search for more papers by this author

Yael A Leshem,

Yael A Leshem

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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Myriam Weyl Ben Arush,

Myriam Weyl Ben Arush

Department of Pediatric Hemato-Oncology, Rambam Health Care Campus, Haifa, Israel

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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Jacob M Rowe,

Jacob M Rowe

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel

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Naim Shehadeh,

Naim Shehadeh

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Department of Pediatrics A, Rambam Health Care Campus, Haifa, Israel

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Ronit Elhasid,

Corresponding Author

Ronit Elhasid

Department of Pediatric Hemato-Oncology, Rambam Health Care Campus, Haifa, Israel

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Yael A Leshem,

Yael A Leshem

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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Myriam Weyl Ben Arush,

Myriam Weyl Ben Arush

Department of Pediatric Hemato-Oncology, Rambam Health Care Campus, Haifa, Israel

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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Jacob M Rowe,

Jacob M Rowe

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel

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Naim Shehadeh,

Naim Shehadeh

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Department of Pediatrics A, Rambam Health Care Campus, Haifa, Israel

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First published: 23 February 2009

https://doi.org/10.1111/j.1399-5448.2008.00420.x

Citations: 5

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Abstract

Objectives: To assess insulin-related metabolism following hematopoietic stem cell transplantation (HSCT) in childhood.

Study design: Thirty-four patients who underwent HSCT were compared with 21 patients with similar diseases who were not transplanted. Median follow-up was 3.6 yr after HSCT. Anthropometric parameters, fasting plasma glucose and insulin levels, hemoglobin A_1c (HbA_1c) and lipid profile were measured and compared.

Results: HbA_1c was significantly higher (p = 0.001) in the study group. Two (5.8%) patients in the study group developed type 2 diabetes mellitus. Among thalassemic patients, significantly lower insulin resistance indices (p = 0.05) and fasting plasma insulin levels (p = 0.033) were found in the study group compared with the control group.

Conclusions: Attentive follow-up of insulin-related metabolism following HSCT in children is needed. The significance of the higher HbA1c values in the study group remains to be evaluated in a larger cohort of patients.

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