Chapter 5

Partitioning into Liposomes

Alex Avdeef

Alex Avdeef

p ION, Inc., USA

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First published: 15 August 2003
Citations: 2

Summary

This chapter considers the special topic of partition coefficients where the lipid phase is made of liposomes formed from vesicles made of bilayers of phospholipids. Enthalpy-driven vs. entropy-driven partioning is considered. Experimental methods are reviewed. The perils of using single-pH measurements is considered. Partitioning into charged liposomes is considered. A list of reliable log P values is compiled.

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