In vitro Activity of Extracts from Polyporaceae against Human Immunodeficiency Virus Type 1
Corresponding Author
R. Walder
Instituto Venezolano de Investigaciones Cientficas (I.V.I.C.) Centro de Microbiologia y Biologia Celular, Laboratorio de Virus Animales, Apartado Postal 21827, Caracas 1020 A, Venezuela
Instituto Venezolano de Investigaciones Cientficas (I.V.I.C.) Centro de Microbiologia y Biologia Celular, Laboratorio de Virus Animales, Apartado Postal 21827, Caracas 1020 A, VenezuelaSearch for more papers by this authorZ. Kalvatchev
Instituto Venezolano de Investigaciones Cientficas (I.V.I.C.) Centro de Microbiologia y Biologia Celular, Laboratorio de Virus Animales, Apartado Postal 21827, Caracas 1020 A, Venezuela
Search for more papers by this authorD. Garzaro
Instituto Venezolano de Investigaciones Cientficas (I.V.I.C.) Centro de Microbiologia y Biologia Celular, Laboratorio de Virus Animales, Apartado Postal 21827, Caracas 1020 A, Venezuela
Search for more papers by this authorM. Barrios
Instituto Venezolano de Investigaciones Cientficas (I.V.I.C.) Centro de Microbiologia y Biologia Celular, Laboratorio de Virus Animales, Apartado Postal 21827, Caracas 1020 A, Venezuela
Search for more papers by this authorCorresponding Author
R. Walder
Instituto Venezolano de Investigaciones Cientficas (I.V.I.C.) Centro de Microbiologia y Biologia Celular, Laboratorio de Virus Animales, Apartado Postal 21827, Caracas 1020 A, Venezuela
Instituto Venezolano de Investigaciones Cientficas (I.V.I.C.) Centro de Microbiologia y Biologia Celular, Laboratorio de Virus Animales, Apartado Postal 21827, Caracas 1020 A, VenezuelaSearch for more papers by this authorZ. Kalvatchev
Instituto Venezolano de Investigaciones Cientficas (I.V.I.C.) Centro de Microbiologia y Biologia Celular, Laboratorio de Virus Animales, Apartado Postal 21827, Caracas 1020 A, Venezuela
Search for more papers by this authorD. Garzaro
Instituto Venezolano de Investigaciones Cientficas (I.V.I.C.) Centro de Microbiologia y Biologia Celular, Laboratorio de Virus Animales, Apartado Postal 21827, Caracas 1020 A, Venezuela
Search for more papers by this authorM. Barrios
Instituto Venezolano de Investigaciones Cientficas (I.V.I.C.) Centro de Microbiologia y Biologia Celular, Laboratorio de Virus Animales, Apartado Postal 21827, Caracas 1020 A, Venezuela
Search for more papers by this authorAbstract
Aqueous extracts of Fomitella supina, Phellinus rhabarbarinus, Trichaptum perrottettii, and Trametes cubensis (Polyporaceae) from the Amazonian rain forest of Venezuela exhibited differential cytotoxicity and inhibitory activity against the human immunodeficiency virus type 1 (HIV-1). These extracts inactivated extracellular virions and suppressed HIV-1 replication by blocking HIV-1-induced cell–cell fusion in an in vitro culture system. They also stimulated interferon (IFN) production, active against HIV-1 and vesicular stomatitis virus (VSV) cytopathic effects. The results suggest that these extracts contain novel anti-HIV active compounds which, individually or in combination, can exert several distinct suppressive effects. The test extracts appear to act specifically at the level of CD4-gp120 binding.
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