The Impact of Hand Edema on Weaning From Mechanical Ventilation in ICU Patients: A Single Center Nested Case-Control Study
Dingye Wu
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorJunfeng Heng
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorFengming Liang
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorTao Zhou
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorQiuhui Wang
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorCorresponding Author
Hongyang Xu
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorDingye Wu
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorJunfeng Heng
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorFengming Liang
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorTao Zhou
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorQiuhui Wang
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorCorresponding Author
Hongyang Xu
Department of Critical Care Medicine , The Affiliated Wuxi People’s Hospital of Nanjing Medical University , No. 299 Qingyang Road, Wuxi , Jiangsu, 214029 , China , njmu.edu.cn
Search for more papers by this authorAbstract
Objective: To investigate the impact of hand edema on weaning from mechanical ventilation among ICU patients.
Methods: A nested case-control study was conducted, collecting data from mechanically ventilated patients admitted to the ICU of Wuxi People’s Hospital from October 1, 2023, to January 31, 2024. Patients were monitored for the occurrence of hand edema within the first 7 days of ICU stay and their weaning outcomes were recorded to analyze the impact of hand edema on weaning success.
Results: The study included 124 patients, 97 successfully weaned while 27 failed. The failed weaning group had higher ages (70.8 ± 10.5 years), SOFA scores (17.7 ± 3.1), and levels of hand edema (Grade 0 in 6 patients, Grade 1 in 9, Grade 2 in 6, Grade 3 in 3, and Grade 4 in 3) compared with the successful weaning group (ages 61.1 ± 9.8 years, SOFA scores 14.3 ± 3.1, hand edema levels: Grade 0 in 78, Grade 1 in 15, Grade 2 in 3, Grade 3 in 1, and Grade 4 in 0). Multivariable binary logistic regression analysis indicated that the level of hand edema is an independent risk factor for weaning failure within 1 week in ICU patients on mechanical ventilation (OR = 3.209, 95% CI: 1.641–6.274, and p < 0.05).
Conclusion: The occurrence of hand edema in ICU patients on mechanical ventilation increases the risk of weaning failure.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The data used to support the findings of this study are available on request from the corresponding author.
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