Therapeutic Potential of Acanthospermum hispidum: A Comprehensive Analysis of Its Antimicrobial, Antioxidant, and Anticancer Properties
Corresponding Author
Ehssan H. Moglad
Department of Pharmaceutics , College of Pharmacy , Prince Sattam bin Abdulaziz University , P.O. Box 173, Alkharj , 11942 , Saudi Arabia , psau.edu.sa
Medicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI) , National Center for Research , P.O. Box 2404, Khartoum , Sudan
Search for more papers by this authorAlshaimaa A. Alnoor
Department of Chemistry , Faculty of Science and Technology , Alneelain University , Khartoum , Sudan , neelain.edu.sd
Search for more papers by this authorNagla M. Eltayeb
Department of Immunology and Biotechnology , Tropical Medicinal Research Institute , National Center for Research , Khartoum , Sudan
Search for more papers by this authorEshtiyag A. Abdalkareem
Department of Immunology and Biotechnology , Tropical Medicinal Research Institute , National Center for Research , Khartoum , Sudan
Search for more papers by this authorAmna Ali
Medicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI) , National Center for Research , P.O. Box 2404, Khartoum , Sudan
Search for more papers by this authorMagbool E. Oraiby
Poison Control and Medical Forensic Chemistry Center , Jazan Health Affairs , Ministry of Health , Jazan , Saudi Arabia , moh.gov.sa
Search for more papers by this authorShahnaz Sultana
Department of Pharmaceutical Chemistry and Pharmacognosy , Faculty of Pharmacy , Jazan University , Jazan , Saudi Arabia , jazanu.edu.sa
Search for more papers by this authorAsaad Khalid
Medicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI) , National Center for Research , P.O. Box 2404, Khartoum , Sudan
Substance Abuse and Toxicology Research Center , Jazan University , P.O. Box 114, Jazan , 45142 , Saudi Arabia , jazanu.edu.sa
Search for more papers by this authorAshraf N. Abdalla
Medicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI) , National Center for Research , P.O. Box 2404, Khartoum , Sudan
Department of Pharmacology and Toxicology , Faculty of Pharmacy , Umm Al Qura University , Makkah , Saudi Arabia , uqu.edu.sa
Search for more papers by this authorCorresponding Author
Ehssan H. Moglad
Department of Pharmaceutics , College of Pharmacy , Prince Sattam bin Abdulaziz University , P.O. Box 173, Alkharj , 11942 , Saudi Arabia , psau.edu.sa
Medicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI) , National Center for Research , P.O. Box 2404, Khartoum , Sudan
Search for more papers by this authorAlshaimaa A. Alnoor
Department of Chemistry , Faculty of Science and Technology , Alneelain University , Khartoum , Sudan , neelain.edu.sd
Search for more papers by this authorNagla M. Eltayeb
Department of Immunology and Biotechnology , Tropical Medicinal Research Institute , National Center for Research , Khartoum , Sudan
Search for more papers by this authorEshtiyag A. Abdalkareem
Department of Immunology and Biotechnology , Tropical Medicinal Research Institute , National Center for Research , Khartoum , Sudan
Search for more papers by this authorAmna Ali
Medicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI) , National Center for Research , P.O. Box 2404, Khartoum , Sudan
Search for more papers by this authorMagbool E. Oraiby
Poison Control and Medical Forensic Chemistry Center , Jazan Health Affairs , Ministry of Health , Jazan , Saudi Arabia , moh.gov.sa
Search for more papers by this authorShahnaz Sultana
Department of Pharmaceutical Chemistry and Pharmacognosy , Faculty of Pharmacy , Jazan University , Jazan , Saudi Arabia , jazanu.edu.sa
Search for more papers by this authorAsaad Khalid
Medicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI) , National Center for Research , P.O. Box 2404, Khartoum , Sudan
Substance Abuse and Toxicology Research Center , Jazan University , P.O. Box 114, Jazan , 45142 , Saudi Arabia , jazanu.edu.sa
Search for more papers by this authorAshraf N. Abdalla
Medicinal and Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI) , National Center for Research , P.O. Box 2404, Khartoum , Sudan
Department of Pharmacology and Toxicology , Faculty of Pharmacy , Umm Al Qura University , Makkah , Saudi Arabia , uqu.edu.sa
Search for more papers by this authorAbstract
Acanthospermum hispidum DC. is a plant with extensive traditional use in folk medicine for treatment of various infections in Sudan including jaundice, stomach discomfort, constipation, and viral infections. This research was carried out to explore the biological and chemical properties of the crude extract of A. hispidum. Ethanol crude extract was prepared from the aerial parts of the plant and investigated for antibacterial action against standard monoderm and diderm bacteria using the cup plate method. Free radical scavenging was investigated out by using the DPPH method. Cytotoxicity assay was performed against human breast cancer cell line MCF7 using the MTT assay. Bioactive compounds were identified using GC-MS. The ethanolic extract of A. hispidum revealed antibacterial activity against all the tested bacteria. Also, the extract exhibited potent antioxidant activity at 0.5 mg/ml using DPPH (83% ± 00.09). The cytotoxicity against MCF7 revealed potent growth inhibition activity (IC50 75.8 µg/ml). GC-MS analysis revealed the presence of ethyl α-d-glucopyranoside, hexadecanoic acid, stigmasterol, β-sitosterol, undecanoic acid, phytol, alloaromadendrene oxide, 3-cyclopentylpropionic acid, 2-dimethylaminoethyl ester, and longifolenaldehyde in aerial parts of A. hispidum, all of which support antibacterial, antioxidant, and cytotoxic properties.
Conflicts of Interest
The authors declare that there are no conflicts of interest.
Open Research
Data Availability
All data generated or analyzed during this study are included in this article.
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