Mixed Epithelial and Stromal Tumor: A Rare Renal Neoplasm—Case Report with Clinicopathologic Features and Review of the Literature
This article is part of Special Issue:
Mukund Tinguria,
Katherine Chorneyko,
Corresponding Author
Mukund Tinguria
Department of Pathology and Laboratory Medicine, Brantford General Hospital, 200 Terrace Hill Street, Brantford, Ontario, Canada Postal Code-N3R 1G9, bchsys.org
Search for more papers by this authorKatherine Chorneyko
Department of Pathology and Laboratory Medicine, Brantford General Hospital, 200 Terrace Hill Street, Brantford, Ontario, Canada Postal Code-N3R 1G9, bchsys.org
Search for more papers by this authorMukund Tinguria,
Katherine Chorneyko,
Corresponding Author
Mukund Tinguria
Department of Pathology and Laboratory Medicine, Brantford General Hospital, 200 Terrace Hill Street, Brantford, Ontario, Canada Postal Code-N3R 1G9, bchsys.org
Search for more papers by this authorKatherine Chorneyko
Department of Pathology and Laboratory Medicine, Brantford General Hospital, 200 Terrace Hill Street, Brantford, Ontario, Canada Postal Code-N3R 1G9, bchsys.org
Search for more papers by this authorAcademic Editor: Yoji Nagashima
Abstract
Mixed epithelial and stromal tumor (MEST) is a rare benign renal neoplasm composed of epithelial and stromal components. Here, we report a 61-year-old woman presenting with a left complex cystic renal mass. The lesion was found incidentally on ultrasound for abdominal discomfort. CT scan and MRI showed a 7.4 cm complex cystic lesion in the left kidney. The differential diagnoses included complex renal cyst and cystic renal cell carcinoma. Laparoscopic nephrectomy showed a large 7.5 cm multicystic tumor with thick and thin septae and smooth walled-cysts containing clear watery fluid. Histologic examination showed variable sized cysts lined by flattened, cuboidal to columnar epithelium with focal hobnailing. No significant cytologic atypia or mitoses were noted. The cyst lining epithelium was positive for CK7 and high molecular weight cytokeratin (34Be12). The stroma was positive for alpha smooth muscle actin, CD10, estrogen receptor, and progesterone receptor. This report contributes an additional case to our collective knowledge of these lesions and summarizes the literature around these rare neoplasms.
Conflicts of Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Open Research
Data Availability
The data used to support the findings of this study are included within the article.
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