[Retracted] Gastrokine 2 Regulates the Antitumor Effect of JAK2/STAT3 Pathway in Gastric Cancer
Retraction(s) for this article
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Retracted: Gastrokine 2 Regulates the Antitumor Effect of JAK2/STAT3 Pathway in Gastric Cancer
- Volume 2023Issue 1Evidence-Based Complementary and Alternative Medicine
- First Published online: June 21, 2023
Yu Zhou
The First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan 422000, China
Shaoyang University, Shaoyang, Hunan 422000, China hnsyu.net
Search for more papers by this authorShan Xu
Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China usc.edu.cn
Search for more papers by this authorJiao Liu
Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China usc.edu.cn
Department of Pathology, Changsha Fourth People’s Hospital, Changsha, Hunan 410006, China
Search for more papers by this authorYaping Zhu
The First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan 422000, China
Shaoyang University, Shaoyang, Hunan 422000, China hnsyu.net
Search for more papers by this authorYaxin Zhu
The First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan 422000, China
Search for more papers by this authorWei Li
Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China usc.edu.cn
Search for more papers by this authorCorresponding Author
Hui Ling
Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China usc.edu.cn
Search for more papers by this authorYu Zhou
The First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan 422000, China
Shaoyang University, Shaoyang, Hunan 422000, China hnsyu.net
Search for more papers by this authorShan Xu
Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China usc.edu.cn
Search for more papers by this authorJiao Liu
Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China usc.edu.cn
Department of Pathology, Changsha Fourth People’s Hospital, Changsha, Hunan 410006, China
Search for more papers by this authorYaping Zhu
The First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan 422000, China
Shaoyang University, Shaoyang, Hunan 422000, China hnsyu.net
Search for more papers by this authorYaxin Zhu
The First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan 422000, China
Search for more papers by this authorWei Li
Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China usc.edu.cn
Search for more papers by this authorCorresponding Author
Hui Ling
Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China usc.edu.cn
Search for more papers by this authorAbstract
GKN2 (gastrokine 2) mainly plays a regulatory role in gastric mucosal defense and cell protection mechanisms, and its role in gastric cancer has not been thoroughly elucidated. Immunohistochemistry was used to detect GKN2 and TFF1 expressions in 90 gastric cancer tissues, 48 neoplastic resection margins, and 22 normal gastric mucosa epithelia. It showed that the downregulation of GKN2 and TFF1 expressions in gastric cancer tissues was significantly different from that in adjacent normal gastric tissues and distal gastric mucosal tissues. Nevertheless, correlation analysis showed that GKN2 expression in gastric cancer tissues was independent of TFF1 expression. After overexpression of GKN2 was constructed in human gastric cancer cell line MKN28 with the Ad-GFP-GKN2 transfected, cell viability was measured by CCK-8 assay, and migration and invasion ability were analyzed by transwell migration assay and transwell invasion assay. It indicated that overexpression of GKN2 significantly reduced the viability of MKN28 and SGC7901 cells. Overexpression of GKN2 could also inhibit the migration and invasion ability in MKN28 and SGC7901 cells. In addition, upregulation of GKN2 can inactivate the JAK2/STAT3 pathway. Our data suggest that GKN2 and TFF1 play the antitumor role in gastric carcinoma, and TFF1 may not interact or cooperate with GKN2. GKN2 overexpression can inhibit the growth and metastasis by downregulating the JAK2/STAT3 pathway in gastric cancer cells.
Conflicts of Interest
The authors declare that they have no conflicts of interest.
Open Research
Data Availability
The results are supported by data from Key Laboratory of Tumor Cellular and Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China.
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