Lepra Reaction with Lucio Phenomenon Mimicking Cutaneous Vasculitis
Corresponding Author
Durga Prasanna Misra
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorJyoti Ranjan Parida
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorAbhra Chandra Chowdhury
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorKrushna Chandra Pani
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorNiraj Kumari
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorNarendra Krishnani
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorVikas Agarwal
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorCorresponding Author
Durga Prasanna Misra
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorJyoti Ranjan Parida
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorAbhra Chandra Chowdhury
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorKrushna Chandra Pani
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorNiraj Kumari
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorNarendra Krishnani
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorVikas Agarwal
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India sgpgi.ac.in
Search for more papers by this authorAbstract
Leprosy is a disease typically found in the tropics. Patients with leprosy can have varying presentation with constitutional symptoms, joint pains, skin nodules, and rarely a vasculitis-like picture with skin ulcers and neuropathy. We present a young lady who presented with the rare manifestation of skin infarcts mimicking cutaneous vasculitis, diagnosed on histopathology to have Lucio phenomenon on a background of lepromatous leprosy. With increasing migration and widespread use of biologic response modifiers, clinicians all over the world need to be aware of various presentations of leprosy as well as needing to keep an open mind while considering the differential diagnoses of vasculitis.
References
- 1 Scollard D. M., Joyce M. P., and Gillis T. P., Development of leprosy and type 1 leprosy reactions after treatment with infliximab: a report of 2 cases, Clinical Infectious Diseases. (2006) 43, no. 2, e19–e22, https://doi.org/10.1086/505222, 2-s2.0-33746705745.
- 2 Oberstein E. M., Kromo O., and Tozman E. C., Type I reaction of Hansen′s disease with exposure to adalimumab: a case report, Arthritis Care & Research. (2008) 59, no. 7, 1040–1043, https://doi.org/10.1002/art.23815, 2-s2.0-47249160781.
- 3 Soni A., Manhas R., John L., Whittam L., and Williamson L., Tropical rheumatology in a UK district general hospital: a case report of leprosy presenting as acute vasculitis, Rheumatology. (2010) 49, no. 4, 826–828, https://doi.org/10.1093/rheumatology/kep405, 2-s2.0-79952469386.
- 4 Chauhan S., Wakhlu A., and Agarwal V., Arthritis in leprosy, Rheumatology. (2010) 49, no. 12, 2237–2242, https://doi.org/10.1093/rheumatology/keq264, 2-s2.0-78549255247.
- 5 Prasad S., Misra R., Aggarwal A., Lawrence A., Haroon N., Wakhlu A., Krishnani N., Agrawal V., Paliwal V. K., Jha S., and Agarwal V., Leprosy revealed in a rheumatology clinic: a case series, International Journal of Rheumatic Diseases. (2013) 16, no. 2, 129–133, https://doi.org/10.1111/j.1756-185x.2012.01819.x, 2-s2.0-84879504199.
- 6 Salvi S. and Chopra A., Leprosy in a rheumatology setting: a challenging mimic to expose, Clinical Rheumatology. (2013) 32, no. 10, 1557–1563, https://doi.org/10.1007/s10067-013-2276-5, 2-s2.0-84885316680.
- 7 Bernadat J. P., Faucher J. F., and Huerre M., Diffuse lepromatous leprosy disclosed by cutaneous vasculitis. The Lucio phenomenon, Annales de Dermatologie et de Vénéréologie. (1996) 123, no. 1, 21–23, 2-s2.0-0029928161.
- 8 Magaña M., Fernández-Díez J., and Magaña M. L., Lucio′s phenomenon is a necrotizing panvasculitis: mostly a medium-sized granulomatous arteritis, The American Journal of Dermatopathology. (2008) 30, no. 6, 555–560, https://doi.org/10.1097/dad.0b013e318181270a, 2-s2.0-59849109155.
- 9 Guedes-Barbosa L. S., Batista E. V., Martins D. C., Neder L., Crepaldi N., and Martins E. V., Necrotizing cutaneous vasculitis in multibacillary leprosy disease (lucio′s phenomenon), Journal of Clinical Rheumatology. (2008) 14, no. 1, 57–59, https://doi.org/10.1097/rhu.0b013e318163bd9a, 2-s2.0-44449143458.
- 10 Sarita S., Muhammed K., Najeeba R., Rajan G. N., Anza K., Binitha M. P., and Aparna G., A study on histological features of lepra reactions in patients attending the Dermatology Department of the Government Medical College, Calicut, Kerala, India, Leprosy Review. (2013) 84, no. 1, 51–64, 2-s2.0-84881349285.
- 11 Curi P. F., Villaroel J. S., Migliore N. et al., Lucio′s phenomenon: report of five cases, Clinical Rheumatology. (2014) https://doi.org/10.1007/s10067-014-2683-2, 2-s2.0-84901575938.
- 12 Fogagnolo L., de Souza E. M., Cintra M. L., and Velho P. E. N. F., Vasculonecrotic reactions in leprosy, The Brazilian Journal of Infectious Diseases. (2007) 11, no. 3, 378–382, https://doi.org/10.1590/s1413-86702007000300016, 2-s2.0-35448955763.
- 13 Chauhan S., D′Cruz S., Mohan H., Singh R., Ram J., and Sachdev A., Type II lepra reaction: an unusual presentation, Dermatology Online Journal. (2006) 12, no. 1, article 18, 2-s2.0-32244434516.
- 14 Sampaio L., Silva L., Terroso G. et al., Hansen′ s disease mimicking a systemic vasculitis, Acta Reumatologica Portuguesa. (2011) 36, no. 1, 61–64, 2-s2.0-79955645753.
- 15 Camps-García T., Pedro I. P.-D., Gómez I. M., Narankiewicz D., Ayala-Gutierrez M., and Sanz-Trelles A., Clinical images: cutaneous necrotizing vasculitis in a patient with lepromatous leprosy, Arthritis and Rheumatism. (2011) 63, no. 11, article 3639, https://doi.org/10.1002/art.30602, 2-s2.0-84872811579.
- 16 Saoji V. and Salodkar A., Lucio leprosy with lucio phenomenon, Indian Journal of Leprosy. (2001) 73, no. 3, 267–272, 2-s2.0-0035211086.
- 17 Kaur C., Thami G. P., and Mohan H., Lucio phenomenon and Lucio leprosy, Clinical and Experimental Dermatology. (2005) 30, no. 5, 525–527, https://doi.org/10.1111/j.1365-2230.2005.01860.x, 2-s2.0-23044434893.
- 18
Kumari R.,
Thappa D. M., and
Basu D., A fatal case of Lucio phenomenon from India, Dermatology Online Journal. (2008) 14, no. 2, article 10, 2-s2.0-41149103857.
10.5070/D347N2B5PZ Google Scholar
- 19
Ranugha P. S. S.,
Chandrashekar L.,
Kumari R.,
Thappa D. M., and
Badhe B., Is it lucio phenomenon or necrotic erythema nodosum leprosum?, Indian Journal of Dermatology. (2013) 58, no. 2, article 160, https://doi.org/10.4103/0019-5154.108087, 2-s2.0-84875724608.
10.4103/0019-5154.108087 Google Scholar
- 20 Pai V. V., Athanikar S., Naveen K. N., Sori T., and Rao R., Lucio phenomenon, Cutis. (2014) 93, no. 2, E12–E14, 2-s2.0-84894080119.