Volume 2013, Issue 1 974614

Research Article

Open Access

Electrical Impedance Spectroscopy as Electrical Biopsy for Monitoring Radiation Sequelae of Intestine in Rats

Pei-Ju Chao

Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan cgu.edu.tw

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Eng-Yen Huang,

Eng-Yen Huang

Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan cgu.edu.tw

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Kuo-Sheng Cheng,

Kuo-Sheng Cheng

Biomedical Imaging and Instrumentation Laboratory, Department of Biomedical Engineering, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan ncku.edu.tw

Medical Device Innovation Center, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan ncku.edu.tw

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Yu-Jie Huang,

Corresponding Author

Yu-Jie Huang

[email protected]

Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan cgu.edu.tw

Biomedical Imaging and Instrumentation Laboratory, Department of Biomedical Engineering, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan ncku.edu.tw

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Pei-Ju Chao,

Pei-Ju Chao

Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan cgu.edu.tw

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Eng-Yen Huang,

Eng-Yen Huang

Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan cgu.edu.tw

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Kuo-Sheng Cheng,

Kuo-Sheng Cheng

Biomedical Imaging and Instrumentation Laboratory, Department of Biomedical Engineering, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan ncku.edu.tw

Medical Device Innovation Center, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan ncku.edu.tw

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Yu-Jie Huang,

Corresponding Author

Yu-Jie Huang

[email protected]

Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan cgu.edu.tw

Biomedical Imaging and Instrumentation Laboratory, Department of Biomedical Engineering, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan ncku.edu.tw

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First published: 04 September 2013

https://doi.org/10.1155/2013/974614

Citations: 8

Academic Editor: Tsair-Fwu Lee

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Abstract

Electrical impedance is one of the most frequently used parameters for characterizing material properties. The resistive and capacitive characteristics of tissue may be revealed by electrical impedance spectroscopy (EIS) as electrical biopsy. This technique could be used to monitor the sequelae after irradiation. In this study, rat intestinal tissues after irradiation were assessed by EIS system based on commercially available integrated circuits. The EIS results were fitted to a resistor-capacitor circuit model to determine the electrical properties of the tissue. The variations in the electrical characteristics of the tissue were compared to radiation injury score (RIS) by morphological and histological findings. The electrical properties, based on receiver operation curve (ROC) analysis, strongly reflected the histological changes with excellent diagnosis performance. The results of this study suggest that electrical biopsy reflects histological changes after irradiation. This approach may significantly augment the evaluation of tissue after irradiation. It could provide rapid results for decision making in monitoring radiation sequelae prospectively.

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