Microencapsulation for the Therapeutic Delivery of Drugs, Live Mammalian and Bacterial Cells, and Other Biopharmaceutics: Current Status and Future Directions
This article is part of Special Issue:
Catherine Tomaro-Duchesneau,
Shyamali Saha,
Meenakshi Malhotra,
Imen Kahouli,
Satya Prakash,
Catherine Tomaro-Duchesneau
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Search for more papers by this authorShyamali Saha
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Faculty of Dentistry, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Search for more papers by this authorMeenakshi Malhotra
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Search for more papers by this authorImen Kahouli
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Department of Experimental Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Search for more papers by this authorCorresponding Author
Satya Prakash
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Search for more papers by this authorCatherine Tomaro-Duchesneau,
Shyamali Saha,
Meenakshi Malhotra,
Imen Kahouli,
Satya Prakash,
Catherine Tomaro-Duchesneau
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Search for more papers by this authorShyamali Saha
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Faculty of Dentistry, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Search for more papers by this authorMeenakshi Malhotra
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Search for more papers by this authorImen Kahouli
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Department of Experimental Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Search for more papers by this authorCorresponding Author
Satya Prakash
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, Canada H3A 2B4, mcgill.ca
Search for more papers by this authorAcademic Editor: Anna Wesolowska
Abstract
Microencapsulation is a technology that has shown significant promise in biotherapeutics, and other applications. It has been proven useful in the immobilization of drugs, live mammalian and bacterial cells and other cells, and other biopharmaceutics molecules, as it can provide material structuration, protection of the enclosed product, and controlled release of the encapsulated contents, all of which can ensure efficient and safe therapeutic effects. This paper is a comprehensive review of microencapsulation and its latest developments in the field. It provides a comprehensive overview of the technology and primary goals of microencapsulation and discusses various processes and techniques involved in microencapsulation including physical, chemical, physicochemical, and other methods involved. It also summarizes the state-of-the-art successes of microencapsulation, specifically with regard to the encapsulation of microorganisms, mammalian cells, drugs, and other biopharmaceutics in various diseases. The limitations and future directions of microencapsulation technologies are also discussed.
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