The Initial Vascular Access Type Contributes to Inflammation in Incident Hemodialysis Patients
Mala Sachdeva
Division of Nephrology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, Centennial Building Room 423, Bronx, NY 10467, USA yu.edu
Search for more papers by this authorAdriana Hung
Division of Nephrology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA vanderbilt.edu
Search for more papers by this authorOleksandr Kovalchuk
Division of Nephrology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, Centennial Building Room 423, Bronx, NY 10467, USA yu.edu
Search for more papers by this authorMarkus Bitzer
Division of Nephrology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, Centennial Building Room 423, Bronx, NY 10467, USA yu.edu
Search for more papers by this authorCorresponding Author
Michele H. Mokrzycki
Division of Nephrology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, Centennial Building Room 423, Bronx, NY 10467, USA yu.edu
Search for more papers by this authorMala Sachdeva
Division of Nephrology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, Centennial Building Room 423, Bronx, NY 10467, USA yu.edu
Search for more papers by this authorAdriana Hung
Division of Nephrology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA vanderbilt.edu
Search for more papers by this authorOleksandr Kovalchuk
Division of Nephrology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, Centennial Building Room 423, Bronx, NY 10467, USA yu.edu
Search for more papers by this authorMarkus Bitzer
Division of Nephrology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, Centennial Building Room 423, Bronx, NY 10467, USA yu.edu
Search for more papers by this authorCorresponding Author
Michele H. Mokrzycki
Division of Nephrology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, Centennial Building Room 423, Bronx, NY 10467, USA yu.edu
Search for more papers by this authorAbstract
Background. The contribution of the hemodialysis (HD) vascular access type to inflammation is unclear. Methods. We conducted a prospective observational study in an incident HD population. C-reactive protein (CRP), interleukin-6 (IL-6), and interferon-γ-induced protein (IP-10) were measured before and at 6-time points after access placement for 1 year. Results. Sixty-four incident HD patients were included (tunneled catheter (TC), n = 40, arteriovenous fistula (AVF), n = 14, and arteriovenous graft (AVG), n = 10). A mixed effects model was performed to adjust for age, sex, race, coronary artery disease, diabetes mellitus, infections, access thrombosis, initiation of HD, and days after access surgery. In comparison to AVFs, the presence of a TC was associated with significantly higher levels of CRP (P = 0.03), IL-6 (P = 0.07), and IP-10 (P = 0.03). The presence of an AVG was associated with increases in CRP (P = 0.01) and IP-10 (P = 0.07). Conclusions. Patients who initiate HD with a TC or an AVG have a heightened state of inflammation, which may contribute to the excess 90-day mortality after HD initiation.
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