Volume 17, Issue 2 728649 pp. 59-65
Article
Open Access

Analysis of Expression Patterns: The Scope of the Problem, the Problem of Scope

Yidong Chen

Yidong Chen

Cancer Genetics Branch National Human Genome Research Institute NIH Bethesda MD 20892, USA , genome.gov

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Zohar Yakhini

Zohar Yakhini

Chemical and Biological Systems Department Agilent Laboratories Palo Alto CA 94304, USA

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Amir Ben-Dor

Amir Ben-Dor

Chemical and Biological Systems Department Agilent Laboratories Palo Alto CA 94304, USA

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Edward Dougherty

Edward Dougherty

Department of Electrical Engineering Texas A & M University College Station TX 77843, USA , tamu.edu

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Jeffrey M. Trent

Jeffrey M. Trent

Cancer Genetics Branch National Human Genome Research Institute NIH Bethesda MD 20892, USA , genome.gov

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Michael Bittner

Corresponding Author

Michael Bittner

Cancer Genetics Branch National Human Genome Research Institute NIH Bethesda MD 20892, USA , genome.gov

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First published: 13 June 2013
Citations: 6

Abstract

Studies of the expression patterns of many genes simultaneously lead to the observation that even in closely related pathologies, there are numerous genes that are differentially expressed in consistent patterns correlated to each sample type. The early uses of the enabling technology, microarrays, was focused on gathering mechanistic biological insights. The early findings now pose another clear challenge, finding ways to effectively use this kind of information to develop diagnostics.

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