The weekend effect in kidney transplantation outcomes: a French cohort-based study
Simon Ville
CRTI UMR 1064, Université de Nantes, ITUN, RTRS Centaure, Inserm, Nantes, France
INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France
Search for more papers by this authorJulien Branchereau
CRTI UMR 1064, Université de Nantes, ITUN, RTRS Centaure, Inserm, Nantes, France
INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France
Search for more papers by this authorAdeline Cornuaud
Centre Hospitalier Universitaire de Nantes, Nantes, France
Search for more papers by this authorJacques Dantal
CRTI UMR 1064, Université de Nantes, ITUN, RTRS Centaure, Inserm, Nantes, France
INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France
Search for more papers by this authorChristophe Legendre
Kidney Transplant Center, Necker University Hospital, APHP, RTRS Centaure, Paris Descartes and Sorbonne Paris Cité Universities, Paris, France
Search for more papers by this authorFanny Buron
Nephrology, Transplantation and Clinical Immunology Department, RTRS Centaure, Edouard Herriot University Hospital, Hospices Civils, Lyon, France
Search for more papers by this authorEmmanuel Morelon
Nephrology, Transplantation and Clinical Immunology Department, RTRS Centaure, Edouard Herriot University Hospital, Hospices Civils, Lyon, France
Search for more papers by this authorValérie Garrigue
Nephrology, Dialysis and Transplantation Department, Lapeyronie University Hospital, Montpellier, France
Search for more papers by this authorMoglie Lequentrec
Nephrology, Dialysis and Transplantation Department, Lapeyronie University Hospital, Montpellier, France
Search for more papers by this authorLaetitia Albano
Department of Nephrology and Renal Transplantation, Hospital Pasteur, Nice, France
Search for more papers by this authorElisabeth Cassuto
Department of Nephrology and Renal Transplantation, Hospital Pasteur, Nice, France
Search for more papers by this authorSophie Girerd
Renal Transplantation Department, Brabois University Hospital, Nancy, France
Search for more papers by this authorMarc Ladrière
Renal Transplantation Department, Brabois University Hospital, Nancy, France
Search for more papers by this authorDenis Glotz
Department of Nephrology and Renal Transplantation, CHU Paris-GH St-Louis Lariboisière, Paris, France
Search for more papers by this authorCarmen Lefaucher
Department of Nephrology and Renal Transplantation, CHU Paris-GH St-Louis Lariboisière, Paris, France
Search for more papers by this authorClarisse Kerleau
CRTI UMR 1064, Université de Nantes, ITUN, RTRS Centaure, Inserm, Nantes, France
INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France
Search for more papers by this authorYohann Foucher
INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France
Centre Hospitalier Universitaire de Nantes, Nantes, France
Search for more papers by this authorCorresponding Author
Magali Giral
CRTI UMR 1064, Université de Nantes, ITUN, RTRS Centaure, Inserm, Nantes, France
Kidney Transplant Center, Necker University Hospital, APHP, RTRS Centaure, Paris Descartes and Sorbonne Paris Cité Universities, Paris, France
Centre d’Investigation Clinique en Biothérapie, Nantes, France
Correspondence
Magali Giral, ITUN - 30, bd Jean Monnet, 44093 Nantes Cedex 01, France.
Tel.: +33 2 40 08 47 69;
e-mail: [email protected]
Search for more papers by this authorfor the DIVAT consortium
Search for more papers by this authorSimon Ville
CRTI UMR 1064, Université de Nantes, ITUN, RTRS Centaure, Inserm, Nantes, France
INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France
Search for more papers by this authorJulien Branchereau
CRTI UMR 1064, Université de Nantes, ITUN, RTRS Centaure, Inserm, Nantes, France
INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France
Search for more papers by this authorAdeline Cornuaud
Centre Hospitalier Universitaire de Nantes, Nantes, France
Search for more papers by this authorJacques Dantal
CRTI UMR 1064, Université de Nantes, ITUN, RTRS Centaure, Inserm, Nantes, France
INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France
Search for more papers by this authorChristophe Legendre
Kidney Transplant Center, Necker University Hospital, APHP, RTRS Centaure, Paris Descartes and Sorbonne Paris Cité Universities, Paris, France
Search for more papers by this authorFanny Buron
Nephrology, Transplantation and Clinical Immunology Department, RTRS Centaure, Edouard Herriot University Hospital, Hospices Civils, Lyon, France
Search for more papers by this authorEmmanuel Morelon
Nephrology, Transplantation and Clinical Immunology Department, RTRS Centaure, Edouard Herriot University Hospital, Hospices Civils, Lyon, France
Search for more papers by this authorValérie Garrigue
Nephrology, Dialysis and Transplantation Department, Lapeyronie University Hospital, Montpellier, France
Search for more papers by this authorMoglie Lequentrec
Nephrology, Dialysis and Transplantation Department, Lapeyronie University Hospital, Montpellier, France
Search for more papers by this authorLaetitia Albano
Department of Nephrology and Renal Transplantation, Hospital Pasteur, Nice, France
Search for more papers by this authorElisabeth Cassuto
Department of Nephrology and Renal Transplantation, Hospital Pasteur, Nice, France
Search for more papers by this authorSophie Girerd
Renal Transplantation Department, Brabois University Hospital, Nancy, France
Search for more papers by this authorMarc Ladrière
Renal Transplantation Department, Brabois University Hospital, Nancy, France
Search for more papers by this authorDenis Glotz
Department of Nephrology and Renal Transplantation, CHU Paris-GH St-Louis Lariboisière, Paris, France
Search for more papers by this authorCarmen Lefaucher
Department of Nephrology and Renal Transplantation, CHU Paris-GH St-Louis Lariboisière, Paris, France
Search for more papers by this authorClarisse Kerleau
CRTI UMR 1064, Université de Nantes, ITUN, RTRS Centaure, Inserm, Nantes, France
INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France
Search for more papers by this authorYohann Foucher
INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France
Centre Hospitalier Universitaire de Nantes, Nantes, France
Search for more papers by this authorCorresponding Author
Magali Giral
CRTI UMR 1064, Université de Nantes, ITUN, RTRS Centaure, Inserm, Nantes, France
Kidney Transplant Center, Necker University Hospital, APHP, RTRS Centaure, Paris Descartes and Sorbonne Paris Cité Universities, Paris, France
Centre d’Investigation Clinique en Biothérapie, Nantes, France
Correspondence
Magali Giral, ITUN - 30, bd Jean Monnet, 44093 Nantes Cedex 01, France.
Tel.: +33 2 40 08 47 69;
e-mail: [email protected]
Search for more papers by this authorfor the DIVAT consortium
Search for more papers by this authorSimon Ville and Julien Branchereau have contributed equally.
Données Informatisées et VAlidées en Transplantation (DIVAT), Collaborators listed in Acknowledgments section.
Summary
Numerous studies have reported a weekend effect on outcomes for diseases treated at hospitals. No study has been conducted in France for kidney transplantation. We therefore performed a cohort-based study to evaluate whether outcomes of kidney transplant recipients display a weekend effect. Data were extracted from the French DIVAT cohort. Patients aged 18 years and older, transplanted with a single kidney from deceased donors between 2005 and 2017 were studied. Linear regression, logistic regression, and cause-specific Cox model were used. Among the 6652 studied patients, 4653 patients were transplanted during weekdays (69.9%) versus 1999 during weekends (30.1%). The only statistically significant difference was the percentage of patients with vascular surgical complication(s) at 30 days: 13.3% in the weekend group versus 16.2% in the weekday group 0.79 (95% CI: 0.68; 0.92). We did not observe other significant differences for the other outcomes: patient or graft survival, the risk of acute rejection episodes, the 30-day percentage of urological complications, and the 1-year estimated glomerular filtration rate. Our study highlights a small protective weekend effect with less post-surgery vascular complications compared to weekdays. This paradox might be explained by a different handling of weekend transplantations.
Conflict of interest
The authors declare that they have no conflict of interest.
Supporting Information
| Filename | Description |
|---|---|
| tri13653-sup-0001-TableS1-S2.docxWord document, 14.9 KB |
Table S1. Hazards Ratios (HR) between weekday and weekend groups according to the calendar period of the transplantation. Table S2. Hazard Ratios (HR) related to the patient and graft survival between weekday and weekend groups according to the center. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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