Retrospective cohort studies of repeat donors reveal donor-dependent variability in the recovery of transfused platelets
Jonathan A. Stefely
Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA
Medical Scientist Training Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA
Co-first authorSearch for more papers by this authorMichael Gailey
Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Co-first authorSearch for more papers by this authorMichael Knudson
Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Search for more papers by this authorLarry J. Dumont
Vitalant Research Institute, Denver, Colorado, USA
Department of Pathology and Laboratory Medicine, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA
Department of Pathology, University of Colorado School of Medicine, Denver, Colorado, USA
Search for more papers by this authorCorresponding Author
Thomas J. Raife
Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA
Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Address reprint requests to: Thomas J. Raife, Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705; e-mail: [email protected]; Noelle I. Samia, Department of Statistics, Northwestern University, Evanston, IL 60208; e-mail: [email protected].Search for more papers by this authorCorresponding Author
Noelle I. Samia
Department of Statistics, Northwestern University, Evanston, Illinois, USA
Address reprint requests to: Thomas J. Raife, Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705; e-mail: [email protected]; Noelle I. Samia, Department of Statistics, Northwestern University, Evanston, IL 60208; e-mail: [email protected].Search for more papers by this authorJonathan A. Stefely
Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA
Medical Scientist Training Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA
Co-first authorSearch for more papers by this authorMichael Gailey
Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Co-first authorSearch for more papers by this authorMichael Knudson
Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Search for more papers by this authorLarry J. Dumont
Vitalant Research Institute, Denver, Colorado, USA
Department of Pathology and Laboratory Medicine, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA
Department of Pathology, University of Colorado School of Medicine, Denver, Colorado, USA
Search for more papers by this authorCorresponding Author
Thomas J. Raife
Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA
Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Address reprint requests to: Thomas J. Raife, Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705; e-mail: [email protected]; Noelle I. Samia, Department of Statistics, Northwestern University, Evanston, IL 60208; e-mail: [email protected].Search for more papers by this authorCorresponding Author
Noelle I. Samia
Department of Statistics, Northwestern University, Evanston, Illinois, USA
Address reprint requests to: Thomas J. Raife, Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705; e-mail: [email protected]; Noelle I. Samia, Department of Statistics, Northwestern University, Evanston, IL 60208; e-mail: [email protected].Search for more papers by this authorAbstract
BACKGROUND
The in vivo recovery of transfused platelets is variable and often unpredictable. Although many recipient-dependent factors are well described, donor-dependent variables remain poorly understood.
STUDY DESIGN AND METHODS
To explore donor-dependent variables we conducted 2 retrospective studies of platelet transfusion outcomes in repeat donors. One study analyzed multiple autologous, radiolabeled platelet transfusions, and a second study analyzed multiple clinical platelet transfusions from a small cohort of repeat donors.
RESULTS
In 36 subjects, multiple within-subject determinations of recovery and survival of radiolabeled autologous platelets revealed a relative consistency in platelet recoveries within donors compared to the range of recoveries among donors. Intraclass correlation coefficients for platelet recovery were 43% to 93%. In 524 ABO-compatible clinical platelet transfusions derived from seven donors, a linear mixed-effects model revealed significant donor-dependent differences in corrected count increments for units stored for 4 or 5 days.
CONCLUSIONS
These two studies indicate reproducible donor-dependent differences in transfused platelet recovery, suggesting a possible heritable influence on the quality of transfused platelets.
CONFLICT OF INTEREST
The authors have disclosed no conflicts of interest.
Supporting Information
| Filename | Description |
|---|---|
| trf15865-sup-0001-supinfo.docxWord 2007 document , 933 KB | Appendix S1: Supporting information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
- 1Kaufman RM, Djulbegovic B, Gernsheimer T, et al. Platelet transfusion: a clinical practice guideline from the AABB. Ann Intern Med 2015; 162: 205-213.
- 2Kumar A, Mhaskar R, Grossman BJ, et al. Platelet transfusion: a systematic review of the clinical evidence. Transfusion 2014; 55: 1116-27.
- 3Solves P, Sanz J, Freiria C, et al. Factors influencing platelet transfusion refractoriness in patients undergoing allogeneic hematopoietic stem cell transplantation. Ann Hematol 2017; 97: 161-7.
- 4Stanworth SJ, Navarrete C, Estcourt L, et al. Platelet refractoriness - practical approaches and ongoing dilemmas in patient management. Br J Haematol 2015; 171: 297-305.
- 5Shrivastava M. The platelet storage lesion. Transfus Apher Sci 2009; 41: 105-13.
- 6Devine DV, Serrano K. The platelet storage lesion. Clin Lab Med 2010; 30: 475-87.
- 7Dern RJ, Wiorkowski JJ. Studies on the preservation of human blood. IV. The hereditary component of pre- and poststorage erythrocyte adenosine triphosphate levels. J Lab Clin Med 1969; 73: 1019-29.
- 8Dern RJ, Brewer GJ, Wiorkowski JJ. Studies on the preservation of human blood. II. The relationship of erythrocyte adenosine triphosphate levels and other in vitro measures to red cell storageability. J Lab Clin Med 1967; 69: 968-78.
- 9Dern RJ, Gwinn RP, Wiorkowski JJ. Studies on the preservation of human blood. I. Variability in erythrocyte storage characteristics among healthy donors. J Lab Clin Med 1966; 67: 955-65.
- 10D'Alessandro A, Kriebardis AG, Rinalducci S, et al. An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies. Transfusion 2015; 55: 205-19.
- 11van't Erve TJ, Doskey CM, Wagner BA, et al. Heritability of glutathione and related metabolites in stored red blood cells. Free Radic Biol Med 2014; 76: 107-13.
- 12Van't Erve TJ, Wagner BA, Martin SM, et al. The heritability of hemolysis in stored human red blood cells. Transfusion 2015; 55: 1178-85.
- 13Van't Erve TJ, Wagner BA, Martin SM, et al. The heritability of metabolite concentrations in stored human red blood cells. Transfusion 2014; 54: 2055-63.
- 14Weisenhorn EMM, Van't Erve TJ, Riley NM, et al. Multi-omics evidence for inheritance of energy pathways in red blood cells. Mol Cell Proteomics 2016; 15: 3614-23.
- 15Dumont LJ, AuBuchon JP. Evaluation of proposed FDA criteria for the evaluation of radiolabeled red cell recovery trials. Transfusion 2008; 48: 1053-60.
- 16Schiffer CA, Lee EJ, Ness PM, et al. Clinical evaluation of platelet concentrates stored for one to five days. Blood 1986; 67: 1591-4.
- 17Hogge D, Thompson B, Schiffer C. Platelet storage for 7 days in second-generation blood bags. Transfusion 1986; 26: 131-5.
- 18Kerkhoffs J-LH, Eikenboom JC, Schipperus MS, et al. A multicenter randomized study of the efficacy of transfusions with platelets stored in platelet additive solution II versus plasma. Blood 2006; 108: 3210-5.
- 19van Rhenen D, Gulliksson H, Cazenave J-P, et al. Transfusion of pooled buffy coat platelet components prepared with photochemical pathogen inactivation treatment: the euroSPRITE trial. Blood 2003; 101: 2426-33.
- 20Anderson NA, Gray S, Copplestone JA, et al. A prospective randomized study of three types of platelet concentrates in patients with haematological malignancy: corrected platelet count increments and frequency of nonhaemolytic febrile transfusion reactions. Transfus Med 1997; 7: 33-9.
- 21Eriksson L, Kristensen J, Olsson K, et al. Evaluation of platelet function using the in vitro bleeding time and corrected count increment of transfused platelets. Comparison between platelet concentrates derived from pooled buffy coates and apheresis. Vox Sang 1996; 70: 69-75.
- 22Davis KB, Slichter SJ, Corash L. Corrected count increment and percent platelet recovery as measures of posttransfusion platelet response: problems and a solution. Transfusion 1999; 39: 586-92.
- 23Slichter SJ, Kaufman RM, Assmann SF, et al. Dose of prophylactic platelet transfusions and prevention of hemorrhage. N Engl J Med 2010; 362: 600-13.
- 24Triulzi DJ, Assmann SF, Strauss RG, et al. The impact of platelet transfusion characteristics on posttransfusion platelet increments and clinical bleeding in patients with hypoproliferative thrombocytopenia. Blood 2012; 119: 5553-62.
- 25Ishida A, Handa M, Wakui M, et al. Clinical factors influencing posttransfusion platelet increment in patients undergoing hematopoietic progenitor cell transplantation–a prospective analysis. Transfusion 1998; 38: 839-47.
- 26Hogge DE, Dutcher JP, Aisner J, et al. Lymphocytotoxic antibody is a predictor of response to random donor platelet transfusion. Am J Hematol 1983; 14: 363-9.
- 27Böck M, Muggenthaler KH, Schmidt U, Heim MU. Influence of antibiotics on posttransfusion platelet increment. Transfusion 1996; 36: 952-954.
- 28Daly PA, Schiffer CA, Aisner J, et al. Platelet transfusion therapy: one-hour posttransfusion increments are valuable in predicting the need for HLA-matched preparations. JAMA 1980; 243: 435-8.
- 29Lee EJ, Schiffer CA. ABO compatibility can influence the results of platelet transfusion. Results of a randomized trial. Transfusion 1989; 29: 384-9.
- 30Dumont LJ, Dumont DF, Unger ZM, et al. A randomized controlled trial comparing autologous radiolabeled in vivo platelet (PLT) recoveries and survivals of 7-day-stored PLT-rich plasma and buffy coat PLTs from the same subjects. Transfusion 2011; 51: 1241-8.
- 31Keegan T, Heaton A, Holme S, et al. Paired comparison of platelet concentrates prepared from platelet-rich plasma and buffy coats using a new technique with 111In and 51Cr. Transfusion 1992; 32: 113-20.
- 32AuBuchon JP, Herschel L, Roger J, et al. Preliminary validation of a new standard of efficacy for stored platelets. Transfusion 2004; 44: 36-41.
- 33Dumont LJ, Cancelas JA, Dumont DF, et al. A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide-frozen autologous platelets in healthy volunteers. Transfusion 2013; 53: 128-37.
- 34Collaborative B. Platelet radiolabeling procedure [1]. Transfusion 2006; 46: 59S-66S.
- 35Lötter MG, Rabe WL, Van Zyl JM, et al. A computer program in compiled basic for the IBM personal computer to calculate the mean platelet survival time with the multiple-hit and weighted mean methods. Comput Biol Med 1988; 18: 305-15.
- 36 R_Core_Team. R: A Language and Environment for Statistical Computing; R Foundation for Statistical Computing, Vienna, Austria. 2013. Available online at https://www.R-project.org/.
- 37Cicchetti DV. Guidelines, criteria, and rules of thumb for evaluating normed and standardized assessment instruments in psychology. Psychol Assess 1994; 6: 284-90.
10.1037/1040-3590.6.4.284 Google Scholar
Citing Literature
