Volume 58, Issue 10 pp. 2365-2373

CELLULAR THERAPIES

Iron overload is correlated with impaired autologous stem cell mobilization and survival in acute myeloid leukemia

Laura C. Alva,

Laura C. Alva

Department of Medical Oncology, Bern University Hospital, University of Bern, Switzerland

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Ulrike Bacher,

Ulrike Bacher

Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Switzerland

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Katja Seipel,

Katja Seipel

Department of Biomedical Research, University of Bern, Bern, Switzerland

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Behrouz Mansouri Taleghani,

Behrouz Mansouri Taleghani

Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Switzerland

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Beatrice U. Mueller,

Beatrice U. Mueller

Department of Biomedical Research, University of Bern, Bern, Switzerland

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Urban Novak,

Urban Novak

Department of Medical Oncology, Bern University Hospital, University of Bern, Switzerland

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Thomas Pabst,

Corresponding Author

Thomas Pabst

[email protected]

Department of Medical Oncology, Bern University Hospital, University of Bern, Switzerland

Address reprint requests to: Thomas Pabst, MD, Associate Professor, Department of Medical Oncology, University Hospital, 3010 Bern, Switzerland; e-mail: [email protected].Search for more papers by this author

Laura C. Alva,

Laura C. Alva

Department of Medical Oncology, Bern University Hospital, University of Bern, Switzerland

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Ulrike Bacher,

Ulrike Bacher

Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Switzerland

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Katja Seipel,

Katja Seipel

Department of Biomedical Research, University of Bern, Bern, Switzerland

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Behrouz Mansouri Taleghani,

Behrouz Mansouri Taleghani

Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Switzerland

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Beatrice U. Mueller,

Beatrice U. Mueller

Department of Biomedical Research, University of Bern, Bern, Switzerland

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Urban Novak,

Urban Novak

Department of Medical Oncology, Bern University Hospital, University of Bern, Switzerland

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Thomas Pabst,

Corresponding Author

Thomas Pabst

[email protected]

Department of Medical Oncology, Bern University Hospital, University of Bern, Switzerland

First published: 10 September 2018

https://doi.org/10.1111/trf.14895

Citations: 11

This study was supported by a grant of the EMPIRIS Foundation (U.Hecht-Fonds) #201501 to TP.

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Abstract

BACKGROUND

Patients with acute myeloid leukemia (AML) undergoing consolidation with autologous stem cell transplantation (ASCT) depend on the successful mobilization of peripheral blood stem cells. However, the factors affecting the mobilization potential in AML patients and, in particular, the effect of transfusion-related iron overload on peripheral blood stem cell mobilization are largely unknown.

STUDY DESIGN AND METHODS

We investigated the association of varying levels of iron overload and stem cell mobilization efficacy in consecutive AML patients after two induction cycles.

RESULTS

A total of 113 AML patients in early first complete remission underwent the mobilization procedure. While 84 (74.3%) patients had serum ferritin levels exceeding 1000 μg/L, 26 (23.0%) patients had levels even higher than 2000 μg/L. Iron overload correlated with the number of preceding red blood cell transfusions and inversely correlated with circulating CD34+ cell levels (p = 0.04) at apheresis. Finally, the median progression-free and overall survival rates of patients with ferritin levels of higher than 2000 μg/L were shorter with 332 days versus 2156 days (p = 0.04) and 852 days versus 2235 days (p = 0.04), respectively.

CONCLUSION

Our data suggest that transfusion-related iron overload is suppressing the mobilization potential and is associated with inferior outcome in AML.

CONFLICT OF INTEREST

The authors have disclosed no conflicts of interest.

Supporting Information

REFERENCES

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Citing Literature

Volume58, Issue10

October 2018

Pages 2365-2373

Iron overload is correlated with impaired autologous stem cell mobilization and survival in acute myeloid leukemia

Abstract

BACKGROUND

STUDY DESIGN AND METHODS

RESULTS

CONCLUSION

CONFLICT OF INTEREST

Supporting Information

REFERENCES

Citing Literature

References

Information

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Iron overload is correlated with impaired autologous stem cell mobilization and survival in acute myeloid leukemia

Abstract

BACKGROUND

STUDY DESIGN AND METHODS

RESULTS

CONCLUSION

CONFLICT OF INTEREST

Supporting Information

REFERENCES

Citing Literature

References

Related

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