Vitamin D and respiratory health in the Busselton Healthy Ageing Study
Corresponding Author
Siobhain Mulrennan
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
Correspondence: Siobhain Mulrennan, Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Perth, WA 6009, Australia. Email: [email protected]Search for more papers by this authorMatthew Knuiman
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Population and Global Health, University of Western Australia, Perth, WA, Australia
Search for more papers by this authorJohn P. Walsh
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA, Australia
Search for more papers by this authorJennie Hui
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Population and Global Health, University of Western Australia, Perth, WA, Australia
PathWest Laboratory Medicine, Perth, WA, Australia
Search for more papers by this authorMichael Hunter
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Population and Global Health, University of Western Australia, Perth, WA, Australia
Search for more papers by this authorMark Divitini
School of Population and Global Health, University of Western Australia, Perth, WA, Australia
Search for more papers by this authorKun Zhu
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA, Australia
Search for more papers by this authorBrian R. Cooke
PathWest Laboratory Medicine, Perth, WA, Australia
Search for more papers by this authorArthur W. (Bill) Musk
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Population and Global Health, University of Western Australia, Perth, WA, Australia
Search for more papers by this authorAlan James
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia
Search for more papers by this authorCorresponding Author
Siobhain Mulrennan
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
Correspondence: Siobhain Mulrennan, Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Perth, WA 6009, Australia. Email: [email protected]Search for more papers by this authorMatthew Knuiman
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Population and Global Health, University of Western Australia, Perth, WA, Australia
Search for more papers by this authorJohn P. Walsh
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA, Australia
Search for more papers by this authorJennie Hui
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Population and Global Health, University of Western Australia, Perth, WA, Australia
PathWest Laboratory Medicine, Perth, WA, Australia
Search for more papers by this authorMichael Hunter
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Population and Global Health, University of Western Australia, Perth, WA, Australia
Search for more papers by this authorMark Divitini
School of Population and Global Health, University of Western Australia, Perth, WA, Australia
Search for more papers by this authorKun Zhu
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA, Australia
Search for more papers by this authorBrian R. Cooke
PathWest Laboratory Medicine, Perth, WA, Australia
Search for more papers by this authorArthur W. (Bill) Musk
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
School of Population and Global Health, University of Western Australia, Perth, WA, Australia
Search for more papers by this authorAlan James
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia
Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia
Search for more papers by this authorABSTRACT
Background and objective
The relationship between vitamin D and respiratory disease was examined by cross-sectional analysis of a large community-based sample.
Methods
Serum 25-hydroxyvitamin D (25OHD) and history of respiratory disease, symptoms (recorded by questionnaire) and spirometry were measured in 5011 adults aged 45–69 years. Adjustments were made for age, sex, season and smoking (Model A), plus body mass index (BMI) and physical activity level (Model B), plus history of chronic diseases (Model C).
Results
Mean (SD) age was 58 (SD 6) years with 45% males, 10% current smokers and 12% taking vitamin D supplements. The prevalence of 25OHD level <50 nmol/L was 8.0%. In all the three models, 25OHD <50 nmol/L was significantly associated with asthma (Model C: odds ratio (OR): 1.32; 95% CI: 1.00, 1.73), bronchitis (1.54; 1.17, 2.01), wheeze (1.37; 1.10, 1.71) and chest tightness (1.42; 1.10, 1.83). Participants with vitamin D level > 100 nmol/L had higher forced vital capacity (FVC) in all the three models (1.17% higher, compared with the 50–100 nmol/L group in Model C).
Conclusion
Low levels of serum 25OHD were independently associated with asthma, bronchitis, wheeze and chest tightness after three levels of adjustment for potential confounders. Higher vitamin D levels were associated with higher levels of lung function.
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