Prevalence of sarcopenia and depressive symptoms among older adults: a scoping review
Keerthana Sree Ganggaya
Nutrition Program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Search for more papers by this authorCorresponding Author
Divya Vanoh
Dietetics Program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Correspondence: Divya Vanoh, PhD, Dietetics Program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia. Email: [email protected]
Search for more papers by this authorWan Rosli Wan Ishak
Nutrition Program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Search for more papers by this authorKeerthana Sree Ganggaya
Nutrition Program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Search for more papers by this authorCorresponding Author
Divya Vanoh
Dietetics Program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Correspondence: Divya Vanoh, PhD, Dietetics Program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia. Email: [email protected]
Search for more papers by this authorWan Rosli Wan Ishak
Nutrition Program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Search for more papers by this authorDisclosure: All authors declare no conflict of interest.
Abstract
Sarcopenia causes a loss of skeletal muscle mass and decreases muscle strength and function. Depressive symptoms are a common cause of distress among geriatrics, significantly affecting the quality of life of older adults. Recently, studies have shown that a correlation exists between sarcopenia and depression. To determine the prevalence of sarcopenia and depressive symptoms and identify the factors associated with sarcopenia, we systematically searched the SCOPUS, Science Direct, and PubMed databases for papers on sarcopenia and depressive symptoms published from 2012 to 2022. We reviewed the literature on sarcopenia, depressive symptom prevalence, the prevalence of subjects with both sarcopenia and depressive symptoms, and the factors associated with sarcopenia. Only cross-sectional studies were included. Nineteen articles met the inclusion criteria for review, with overall sarcopenia prevalence ranging from 3.9% to 41.7%. The prevalence of depressive symptoms was reported in seven studies, ranging from 8.09% to 40%. The most commonly used tools to diagnose sarcopenia and depressive symptoms were the European Working Group on Sarcopenia in Older People consensus and the Geriatric Depression Scale, respectively. Being aged, malnourished, obese, having comorbidities (hypertension and diabetes), having impaired cognitive function, and having polypharmacy were found to be the factors associated with sarcopenia. Sarcopenia and depressive symptoms have been found to cause adverse health outcomes among older people. Appropriate nutritional assessments and interventions should be taken to manage these two geriatric conditions. Further studies should be planned, considering multidomain intervention strategies to improve sarcopenia and older people's mental health.
Open Research
DATA AVAILABILITY STATEMENT
Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
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REFERENCES
- 1Xu Q, Ou X, Li J. The risk of falls among the aging population: a systematic review and meta-analysis. Front Public Health 2022; 10: 902599.
- 2Boz E, Cerutti E, Pugacheva E. Dissecting the global trade slowdown: a new database, Forth-coming IMF Working Paper 2019.
- 3Harper S. Living longer within ageing societies. J Popul Ageing 2019; 12: 133–136.
- 4Cristea M, Noja GG, Dănăcică DE, Ştefea P. Population ageing, labour productivity and economic welfare in the European Union. Econ Res Ekon Istraz 2020; 33: 1354–1376.
- 5Smulyanskaya NS. Factors of fertility ageing rate. Popul Econ 2020; 4: 60–74.
10.3897/popecon.4.e53039 Google Scholar
- 6Young F, Maguire S. Physiology of ageing. Anaesth Intensive Care Med. 2019; 20: 735–738.
- 7Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr 1997; 127: 990s–991s.
- 8Cruz-Jentoft AJ, Baeyens JP, Bauer JM et al. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. Age Ageing 2010; 39: 412–423.
- 9Cruz-Jentoft AJ, Bahat G, Bauer J et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019; 48: 16–31.
- 10Chen LK, Woo J, Assantachai P et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc 2020; 21: 300–307.e2.
- 11Anker SD, Morley JE, von Haehling S. Welcome to the ICD-10 code for sarcopenia. J Cachexia Sarcopenia Muscle 2016; 7: 512–514.
- 12Wilkinson DJ, Piasecki M, Atherton PJ. The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans. Ageing Res Rev 2018; 47: 123–132.
- 13von Haehling S, Morley JE, Anker SD. An overview of sarcopenia: facts and numbers on prevalence and clinical impact. J Cachexia Sarcopenia Muscle 2010; 1: 129–133.
- 14Petermann-Rocha F, Balntzi V, Gray SR et al. Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 2022; 13: 86–99.
- 15Mayhew AJ, Amog K, Phillips S et al. The prevalence of sarcopenia in community-dwelling older adults, an exploration of differences between studies and within definitions: a systematic review and meta-analyses. Age Ageing 2019; 48: 48–56.
- 16Yang L, Smith L, Hamer M. Gender-specific risk factors for incident sarcopenia: 8-year follow-up of the English longitudinal study of ageing. J Epidemiol Community Health 2019; 73: 86–88.
- 17Chang CF, Yeh YL, Chang HY, Tsai SH, Wang JY. Prevalence and risk factors of sarcopenia among older adults aged ≥65 years admitted to daycare centers of Taiwan: using AWGS 2019 guidelines. Int J Environ Res Public Health 2021; 18: 8299.
- 18Therakomen V, Petchlorlian A, Lakananurak N. Prevalence and risk factors of primary sarcopenia in community-dwelling outpatient elderly: a cross-sectional study. Sci Rep 2020; 10: 19551.
- 19Sri-on J, Fusakul Y, Kredarunsooksree T, Paksopis T, Ruangsiri R. The prevalence and risk factors of sarcopenia among Thai community-dwelling older adults as defined by the Asian Working Group for Sarcopenia (AWGS-2019) criteria: a cross-sectional study. BMC Geriatr 2022; 22: 786.
- 20Beaudart C, Zaaria M, Pasleau F, Reginster JY, Bruyère O. Health outcomes of sarcopenia: a systematic review and meta-analysis. PLoS One 2017; 12: e0169548.
- 21von Zimmermann C, Winkelmann M, Richter-Schmidinger T, Mühle C, Kornhuber J, Lenz B. Physical activity and body composition are associated with severity and risk of depression, and serum lipids. Front Psych 2020; 11: 494.
- 22Speed MS, Jefsen OH, Børglum AD, Speed D, Østergaard SD. Investigating the association between body fat and depression via Mendelian randomization. Transl Psychiatry 2019; 9: 184.
- 23Li Z, Tong X, Ma Y, Bao T, Yue J. Prevalence of depression in patients with sarcopenia and correlation between the two diseases: systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 2022; 13: 128–144.
- 24Szlejf C, Suemoto CK, Brunoni AR et al. Depression is associated with sarcopenia due to low muscle strength: results from the ELSA-Brasil study. J Am Med Dir Assoc 2019; 20: 1641–1646.
- 25Zenebe Y, Akele B, Selassie M, Necho M. Prevalence and determinants of depression among old age: a systematic review and meta-analysis. Ann Gen Psychiatry 2021; 20: 55.
- 26Kasa AS, Lee S-C, Chang H-C. Prevalence and factors associated with depression among older adults in the case of a low-income country, Ethiopia: a systematic review and meta-analysis. BMC Psychiatry 2022; 22: 675.
- 27Mulat N, Gutema H, Wassie GT. Correction to: prevalence of depression and associated factors among elderly people in Womberma District, North-West, Ethiopia. BMC Psychiatry 2021; 21: 195.
- 28Aung TNN, Moolphate S, Koyanagi Y et al. Determinants of health-related quality of life among community-dwelling Thai older adults in Chiang Mai, Northern Thailand. Risk Manag Healthc Policy 2022; 15: 1761–1774.
- 29Pilania M, Yadav V, Bairwa M et al. Prevalence of depression among the elderly (60 years and above) population in India, 1997–2016: a systematic review and meta-analysis. BMC Public Health 2019; 19: 832.
- 30Lee HJ, Lee DK, Song W. Relationships between social capital, social capital satisfaction, self-esteem, and depression among elderly urban residents: analysis of secondary survey data. Int J Environ Res Public Health 2019; 16: 1445.
- 31Wu D, Liu F, Huang S. Assessment of the relationship between living alone and the risk of depression based on longitudinal studies: a systematic review and meta-analysis. Front Psychiatry 2022; 13: 954857.
- 32Hossain B, Nagargoje VP, Sk MIK, Das J. Social exclusion and mental health among older adults: cross-sectional evidence from a population-based survey in India. BMC Psychiatry 2022; 22: 409.
- 33Seo J, Choi B, Kim S, Lee H, Oh D. The relationship between multiple chronic diseases and depressive symptoms among middle-aged and elderly populations: results of a 2009 korean community health survey of 156,747 participants. BMC Public Health 2017; 17: 844.
- 34Jun H, Aguila E. Private insurance and mental health among older adults with multiple chronic conditions: a longitudinal analysis by race and ethnicity. Int J Environ Res Public Health 2021; 18: 2615.
- 35Wu Z, Yue Q, Zhao Z et al. A cross-sectional study of smoking and depression among US adults: NHANES (2005–2018). Front Public Health 2023; 11: 1081706.
- 36Li Y, Scherer N, Felix L, Kuper H. Prevalence of depression, anxiety and post-traumatic stress disorder in health care workers during the COVID-19 pandemic: a systematic review and meta-analysis. PLoS One 2021; 16: e0246454.
- 37Zakharova A, Kabasawa K, Ito Y et al. Association between sarcopenia and depressive symptoms in community-dwelling people aged 40 years and older. Tohoku J Exp Med 2022; 257: 117–125.
- 38Yuenyongchaiwat K, Boonsinsukh R. Sarcopenia and its relationships with depression, cognition, and physical activity in Thai community-dwelling older adults. Curr Gerontol Geriatr Res 2020; 2020: 1–6.
10.1155/2020/8041489 Google Scholar
- 39Chang KV, Hsu TH, Wu WT, Huang KC, Han DS. Is sarcopenia associated with depression? a systematic review and meta-analysis of observational studies. Age Ageing 2017; 46: 738–746.
- 40Imaoka M, Nakao H, Nakamura M et al. Associations between depressive symptoms and geriatric syndromes in community-dwelling older adults in Japan: a cross-sectional study. Prev Med Rep 2021; 22: 101353.
- 41Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 6: e1000097.
- 42 National Health L, and Blood Institute Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies 2021. Available from: https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools.
- 43Badrasawi M, Jarradat A, Khodour Z, Lahaleh R, Irshaied A. Sarcopenia prevalence and its correlations with age-related disorders among community-dwelling palestinian older adults. J Gerontol Geriatr 2020; 68: 126–135.
- 44Chen L, Sheng Y, Qi H, Tang T, Yu J, Lv S. Correlation of sarcopenia and depressive mood in older community dwellers: a cross-sectional observational study in China. BMJ Open 2020; 10: e038089.
- 45Cheng L, Sit JWH, Chan HYL et al. Sarcopenia risk and associated factors among Chinese community-dwelling older adults living alone. Sci Rep 2021; 11: 22219.
- 46Cipolli GC, Aprahamian I, Borim FSA et al. Probable sarcopenia is associated with cognitive impairment among community-dwelling older adults: results from the FIBRA study. Arq Neuropsiquiatr 2021; 79: 376–383.
- 47Delibaş DH, Eşkut N, İlhan B et al. Clarifying the relationship between sarcopenia and depression in geriatric outpatients. Aging Male 2021; 24: 29–36.
- 48de Souza LF, Fontanela LC, Gonçalves C et al. Cognitive and behavioral factors associated to probable sarcopenia in community-dwelling older adults. Exp Aging Res 2022; 48: 150–163.
- 49Samper-Ternent R, Reyes-Ortiz C, Ottenbacher KJ, Cano CA. Frailty and sarcopenia in Bogotá: results from the SABE Bogotá Study. Aging Clin Exp Res 2017; 29: 265–272.
- 50Patino-Hernandez D, David-Pardo DG, Borda MG, Pérez-Zepeda MU, Cano-Gutiérrez C. Association of fatigue with sarcopenia and its elements: a secondary analysis of SABE-Bogotá. Gerontol Geriatr Med 2017; 3: 1–7.
- 51Kilavuz A, Meseri R, Savas S et al. Association of sarcopenia with depressive symptoms and functional status among ambulatory community-dwelling elderly. Arch Gerontol Geriatr 2018; 76: 196–201.
- 52Hayashi T, Umegaki H, Makino T, Cheng XW, Shimada H, Kuzuya M. Association between sarcopenia and depressive mood in urban-dwelling older adults: a cross-sectional study. Geriatr Gerontol Int 2019; 19: 508–512.
- 53Chen X, Hou L, Zhang Y, Dong B. Analysis of the prevalence of sarcopenia and its risk factors in the elderly in the Chengdu community. J Nutr Health Aging 2021; 25: 600–605.
- 54Zhang HY, Chong MC, Tan MP, Chua YP, Zhang JH. The association between depressive symptoms and sarcopenia among community-dwelling older adults: a cross-sectional study. J Multidiscip Healthc 2022; 15: 837–846.
- 55Wang LT, Huang WC, Hung YC, Park JH. Association between depressive symptoms and risk of sarcopenia in Taiwanese older adults. J Nutr Health Aging 2021; 25: 790–794.
- 56Wang H, Hai S, Liu Y et al. Association between depressive symptoms and sarcopenia in older Chinese community-dwelling individuals. Clin Interv Aging 2018; 13: 1605–1611.
- 57Su Y, Hirayama K, Han TF, Izutsu M, Yuki M. Sarcopenia prevalence and risk factors among Japanese community dwelling older adults living in a snow-covered city according to EWGSOP2. J Clin Med 2019; 8: 291.
- 58Öztürk ZA, Türkbeyler İH, Abiyev A et al. Health-related quality of life and fall risk associated with age-related body composition changes; sarcopenia, obesity and sarcopenic obesity. Intern Med J 2018; 48: 973–981.
- 59Lee I, Cho J, Hong H, Jin Y, Kim D, Kang H. Sarcopenia is associated with cognitive impairment and depression in elderly Korean women. Iran J Public Health 2018; 47: 327–334.
- 60Endo T, Akai K, Kijima T et al. An association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: a cross-sectional analysis. PLoS One 2021; 16: e0252784.
- 61Dharmakulsakti P, Roopsawang I, Aree-Ue S. Sarcopenia among older adults with knee osteoarthritis: a cross-sectional study of prevalence and its associated factors. Pac Rim Int J Nurs Res 2022; 26: 121–134.
- 62Chen X, Guo J, Han P et al. Twelve-month incidence of depressive symptoms in suburb-dwelling Chinese older adults: role of sarcopenia. J Am Med Dir Assoc 2019; 20: 64–69.
- 63Ren X, Zhang X, He Q et al. Prevalence of sarcopenia in Chinese community-dwelling elderly: a systematic review. BMC Public Health 2022; 22: 1702.
- 64Liu X, Hou L, Xia X et al. Prevalence of sarcopenia in multi ethnics adults and the association with cognitive impairment: findings from West-China health and aging trend study. BMC Geriatr 2020; 20: 63.
- 65Guillamón-Escudero C, Diago-Galmés A, Tenías J, Soriano JM, Fernández-Garrido J. Prevalence of sarcopenia in community-dwelling older adults in Valencia, Spain. Int J Environ Res Public Health 2020; 17: 9130.
- 66Chew STH, Tey SL, Yalawar M et al. Prevalence and associated factors of sarcopenia in community-dwelling older adults at risk of malnutrition. BMC Geriatr 2022; 22: 997.
- 67Du Y, Wang X, Xie H et al. Sex differences in the prevalence and adverse outcomes of sarcopenia and sarcopenic obesity in community dwelling elderly in East China using the AWGS criteria. BMC Endocr Disord 2019; 19: 109.
- 68Yang Y, Zhang Q, He C et al. Prevalence of sarcopenia was higher in women than in men: a cross-sectional study from a rural area in eastern China. PeerJ 2022; 10: e13678.
- 69Hwang J, Park S. Sex differences of sarcopenia in an elderly Asian population: the prevalence and risk factors. Int J Environ Res Public Health 2022; 19: 11980.
- 70Geraci A, Calvani R, Ferri E, Marzetti E, Arosio B, Cesari M. Sarcopenia and menopause: the role of estradiol. Front Endocrinol (Lausanne). 2021; 12: 682012.
- 71Cheng KY, Chow SK, Hung VW et al. Diagnosis of sarcopenia by evaluating skeletal muscle mass by adjusted bioimpedance analysis validated with dual-energy X-ray absorptiometry. J Cachexia Sarcopenia Muscle 2021; 12: 2163–2173.
- 72Choi S, Chon J, Lee SA et al. Central obesity is associated with lower prevalence of sarcopenia in older women, but not in men: a cross-sectional study. BMC Geriatr 2022; 22: 406.
- 73Achamrah N, Colange G, Delay J et al. Comparison of body composition assessment by DXA and BIA according to the body mass index: a retrospective study on 3655 measures. PLoS One 2018; 13: e0200465.
- 74Xia L, Zhao R, Wan Q et al. Sarcopenia and adverse health-related outcomes: an umbrella review of meta-analyses of observational studies. Cancer Med 2020; 9: 7964–7978.
- 75Huang JH, Li RH, Tsai LC. Relationship between depression with physical activity and obesity in older diabetes patients: inflammation as a mediator. Nutrients 2022; 14: 4200.
- 76Arosio B, Guerini FR, Voshaar RCO, Aprahamian I. Blood brain-derived neurotrophic factor (BDNF) and major depression: do we have a translational perspective? Front Behav Neurosci 2021; 15: 626906.
- 77Oudbier SJ, Goh J, Looijaard SMLM, Reijnierse EM, Meskers CGM, Maier AB. Pathophysiological mechanisms explaining the association between low skeletal muscle mass and cognitive function. J Gerontol A Biol Sci Med Sci 2022; 77: 1959–1968.
- 78Ustevic C, Rajovic N, Stanisavljevic D et al. From sarcopenia to depressive symptoms in elderly: a path analysis. Int J Environ Res Public Health 2023; 20: 972.
- 79Barclay RD, Burd NA, Tyler C, Tillin NA, Mackenzie RW. The role of the IGF-1 signaling cascade in muscle protein synthesis and anabolic resistance in aging skeletal muscle. Front Nutr 2019; 6: 146.
- 80Lee K, Shin Y, Huh J et al. Recent issues on body composition imaging for sarcopenia evaluation. Korean J Radiol 2019; 20: 205–217.
- 81Scisciola L, Fontanella RA, Surina CV, Paolisso G, Barbieri M. Sarcopenia and cognitive function: role of myokines in muscle brain cross-talk. Life (Basel) 2021; 11: 173.
- 82Jo D, Yoon G, Kim OY, Song J. A new paradigm in sarcopenia: cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction. Biomed Pharmacother 2022; 147: 112636.
- 83Roh E, Choi KM. Health consequences of sarcaopenic obesity: a narrative review. Front Endocrinol (Lausanne) 2020; 11: 332.
- 84Mathewson SL, Azevedo PS, Gordon AL, Phillips BE, Greig CA. Overcoming protein-energy malnutrition in older adults in the residential care setting: a narrative review of causes and interventions. Ageing Res Rev 2021; 70: 101401.
- 85Sieber CC. Malnutrition and sarcopenia. Aging Clin Exp Res 2019; 31: 793–798.
- 86Lardiés-Sánchez B, París A. Sarcopenia and Malnutrition in the Elderly, 2017.
- 87König M, Spira D, Demuth I, Steinhagen-Thiessen E, Norman K. Polypharmacy as a risk factor for clinically relevant sarcopenia: results from the Berlin aging study II. J Gerontol Series A 2018; 73: 117–122.
- 88Pana A, Sourtzi P, Kalokairinou A, Pastroudis A, Chatzopoulos S-T, Velonaki VS. Association between muscle strength and sleep quality and duration among middle-aged and older adults: a systematic review. Eur Geriatr Med 2021; 12: 27–44.
- 89Bai T, Fang F, Li F, Ren Y, Hu J, Cao J. Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis. BMC Geriatr 2020; 20: 279.
- 90Martins Junior FAD, Mateo DPA, Silva FJM et al. Use of diuretics is associated with higher risk of sarcopenia in older adults with hypertension. Int J Cardiovasc Sci 2022; 35: 476–485.
- 91Qiao YS, Chai YH, Gong HJ et al. The association between diabetes mellitus and risk of sarcopenia: accumulated evidences from observational studies. Front Endocrinol (Lausanne) 2021; 12: 782391.
- 92Wang PY, Chen XK, Liu Q et al. Highlighting sarcopenia management for promoting surgical outcomes in esophageal cancers: evidence from a prospective cohort study. Int J Surg 2020; 83: 206–215.
- 93Tzeng P-L, Lin C-Y, Lai T-F et al. Daily lifestyle behaviors and risks of sarcopenia among older adults. Arch Public Health 2020; 78: 113.
- 94Lorenzo I, Serra-Prat M, Yébenes JC. The role of water homeostasis in muscle function and frailty: a review. Nutrients 2019; 11: 1857.
- 95Guan Y, Yan Z. Molecular mechanisms of exercise and healthspan. Cells 2022; 11: 872.