Ovarian high-grade endometrioid stromal sarcoma with YWHAE and NUTM2B rearrangements
Noriaki Kikuchi
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorShintaro Sugita
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorKatsuya Nakanishi
Department of Surgical Pathology, Japan Community Health Care Organization Sapporo Hokushin Hospital, 2-6-2 Atsubetsuchuo, Atsubetsu-ku, Sapporo, Hokkaido 004-8618, Japan
Search for more papers by this authorTaro Sugawara
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorKeiko Segawa
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorYumika Ito
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorTerufumi Kubo
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorHiromi Fujita
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorHiroshi Hirano
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorRyoichi Tanaka
Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorTsuyoshi Saito
Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorTadashi Hasegawa
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorNoriaki Kikuchi
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorShintaro Sugita
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorKatsuya Nakanishi
Department of Surgical Pathology, Japan Community Health Care Organization Sapporo Hokushin Hospital, 2-6-2 Atsubetsuchuo, Atsubetsu-ku, Sapporo, Hokkaido 004-8618, Japan
Search for more papers by this authorTaro Sugawara
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorKeiko Segawa
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorYumika Ito
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorTerufumi Kubo
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorHiromi Fujita
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorHiroshi Hirano
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorRyoichi Tanaka
Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorTsuyoshi Saito
Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this authorTadashi Hasegawa
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan
Search for more papers by this author
Supporting Information
Additional Supporting Information may be found in the online version of this article at the publisher's website.
| Filename | Description |
|---|---|
| pin12542-sup-0001-SuppFig-S1.tif2.7 MB |
Figure S1 MRI findings of OHGESS. (a) Sagittal T2-weighted image showing a multinodular mass compressing the anterior wall of the atrophic uterine corpus. The mass exhibited heterogeneous linear intermediate-intensity and high-intensity signals and had areas of extensive liquefactive degeneration in the lower part of the mass. (b) Axial T2-weighted image showing a multinodular mass. The right side of the mass shows homogeneous intermediate-intensity signal areas, the left side of the mass exhibits heterogeneous irregular-intensity areas corresponding to the areas of degeneration. The tumor is invading the ovarian vein adjacent to the mass (arrow). |
| pin12542-sup-0002-SuppFig-S2.tif6.3 MB |
Figure S2 Additional pathological findings of OHGESS. (a) Macroscopic view of the right ovarian tumor showing marked enlargement of the right ovary. On cross-section, the tumor was composed of milky-whitish, solid areas and focally cystic areas with necrosis or degeneration. These areas corresponded well to the MRI findings. (b) Tumor cells were positive for c-kit on IHC. (c) Tumor cells were positive for CD34 on IHC. (d) FISH of NUTM2B split signals. NUTM2B split signals with one isolated green (arrow head) and two fused yellow (arrow) signals. This signal pattern suggested an imbalanced chromosomal translocation of the NUTM2B gene. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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