Failure to Rescue Pediatric Recipients of Living Donor Liver Transplantation: A Single-Center Study of Technical Complications in 500 Primary Grafts
This article relates to:
-
Failure to Rescue: Moving From Concept to Method
- Volume 28Issue 8Pediatric Transplantation
- First Published online: November 11, 2024
Corresponding Author
Aniss Channaoui
Pediatric Surgery and Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Correspondence:
Aniss Channaoui ([email protected])
Search for more papers by this authorCatherine de Magnée
Pediatric Surgery and Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorRoberto Tambucci
Pediatric Surgery and Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorEliano Bonaccorsi-Riani
Abdominal Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorThierry Pirotte
Department of Anesthesiology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorNatalia Magasich-Airola
Department of Anesthesiology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorThierry Detaille
Pediatric Intensive Care Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorLaurent Houtekie
Pediatric Intensive Care Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorRenaud Menten
Pediatric Radiology Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorDana Dumitriu
Pediatric Radiology Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorMarguerite van den Hove
Pediatric Surgery and Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorPamela Baldin
Department of Pathology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorFrançoise Smets
Division of Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorIsabelle Scheers
Division of Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorGiulia Jannone
Division of Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorEtienne Sokal
Division of Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorXavier Stephenne
Division of Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorRaymond Reding
Pediatric Surgery and Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorCorresponding Author
Aniss Channaoui
Pediatric Surgery and Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Correspondence:
Aniss Channaoui ([email protected])
Search for more papers by this authorCatherine de Magnée
Pediatric Surgery and Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorRoberto Tambucci
Pediatric Surgery and Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorEliano Bonaccorsi-Riani
Abdominal Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorThierry Pirotte
Department of Anesthesiology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorNatalia Magasich-Airola
Department of Anesthesiology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorThierry Detaille
Pediatric Intensive Care Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorLaurent Houtekie
Pediatric Intensive Care Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorRenaud Menten
Pediatric Radiology Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorDana Dumitriu
Pediatric Radiology Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorMarguerite van den Hove
Pediatric Surgery and Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorPamela Baldin
Department of Pathology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorFrançoise Smets
Division of Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorIsabelle Scheers
Division of Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorGiulia Jannone
Division of Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorEtienne Sokal
Division of Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorXavier Stephenne
Division of Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorRaymond Reding
Pediatric Surgery and Transplant Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Search for more papers by this authorFunding: The authors received no specific funding for this work.
Presented at the 79th French Congress of Pediatric Surgery (Poitiers, September 20–22, 2023), at the Belgian 2024 Transplantation Society Congress (Brussels, March 15, 2024), and by poster presentation at the 2023 European Society for Organ Transplantation Congress (Athens, September 17–20, 2023).
ABSTRACT
Background
The concept of failure to rescue (FTR) has been used to evaluate the quality of care in several surgical specialties but has not been well-studied after living donor liver transplantation (LDLT) in children.
Methods
This study retrospectively reviewed 500 pediatric LDLT performed at a single center between 1993 and 2022. The recipient outcomes were assessed by means of patient and graft survival rates, retransplantation rates, and arterial/portal/biliary complication rates. Graft and patient losses secondary to these complications were calculated regarding FTR for patients (FTRp) and grafts (FTRg).
Results
Overall 1- and 5-year patient survival rates were 94.5% and 92.1%, respectively, the corresponding figures for graft survival being 92.7% and 89.8%. One-year hepatic artery complication rate was 3.6% (n = 18 cases), the respective rates for portal vein complications and biliary complications being 5.7% (n = 57) and 15.6% (n = 101). One-year FTRp rates for hepatic artery thrombosis, portal vein thrombosis, anastomotic biliary stricture, and intrahepatic biliary stricture were 28.6%, 9.4%, 3.6%, and 0%, respectively. The corresponding FTRg rates being 21.4%, 6.3%, 0%, and 36.4%.
Conclusion
Such novel analytical method may offer valuable insights for optimizing quality of care in pediatric LDLT.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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