Ribavirin therapy of hepatitis E infection may cause hyporegenerative anemia in pediatric renal transplant patients
Corresponding Author
Verena Klämbt
Faculty of Medicine, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University Freiburg, University of Freiburg, Freiburg, Germany
Correspondence
Verena Klämbt, Faculty of Medicine, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University Freiburg, University of Freiburg, Freiburg, Germany.
Email: [email protected]
Search for more papers by this authorMarcus Panning
Faculty of Medicine, Institute of Virology, University of Freiburg, Freiburg, Germany
Search for more papers by this authorMaximilian Seidl
Faculty of Medicine, Institute of Pathology, University of Freiburg, Freiburg, Germany
Search for more papers by this authorKarsten Häffner
Faculty of Medicine, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University Freiburg, University of Freiburg, Freiburg, Germany
Search for more papers by this authorMartin Pohl
Faculty of Medicine, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University Freiburg, University of Freiburg, Freiburg, Germany
Search for more papers by this authorCorresponding Author
Verena Klämbt
Faculty of Medicine, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University Freiburg, University of Freiburg, Freiburg, Germany
Correspondence
Verena Klämbt, Faculty of Medicine, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University Freiburg, University of Freiburg, Freiburg, Germany.
Email: [email protected]
Search for more papers by this authorMarcus Panning
Faculty of Medicine, Institute of Virology, University of Freiburg, Freiburg, Germany
Search for more papers by this authorMaximilian Seidl
Faculty of Medicine, Institute of Pathology, University of Freiburg, Freiburg, Germany
Search for more papers by this authorKarsten Häffner
Faculty of Medicine, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University Freiburg, University of Freiburg, Freiburg, Germany
Search for more papers by this authorMartin Pohl
Faculty of Medicine, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University Freiburg, University of Freiburg, Freiburg, Germany
Search for more papers by this authorAbstract
HEV infection can lead to chronic hepatitis in immunosuppressed patients; extrahepatic manifestations are rarely seen. Here, we report a 13-year-old renal transplant patient with chronic hepatitis E and renal involvement. Ribavirin therapy led to temporary virus clearance and amelioration of kidney function. However, ribavirin therapy caused severe hyporegenerative anemia, which has so far only been reported in patients treated with a combination of ribavirin and interferon alpha.
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