Successful liver transplantation for non-resectable desmoplastic nested spindle cell tumor complicated by Cushing's syndrome
Corresponding Author
Sarah Tehseen
Department of Pediatrics, Division of Pediatric Hematology Oncology (Aflac Cancer and Blood Disorders Center), Emory University, Atlanta, GA, USA
Department of Pediatrics, Division of Pediatric Gastroenterology, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA
Correspondence
Sarah Tehseen, Department of Pediatrics, Division of Pediatric Hematology Oncology (Aflac Cancer and Blood Disorders Center), Emory University, Atlanta, GA, USA
Email: [email protected]
Search for more papers by this authorLouis Rapkin
Department of Pediatrics, Division of Pediatric Hematology Oncology (Aflac Cancer and Blood Disorders Center), Emory University, Atlanta, GA, USA
Department of Pediatrics, Division of Pediatric Gastroenterology, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA
Search for more papers by this authorErwin Schemankewitz
Department of Pathology, Children's Healthcare of Atlanta, Atlanta, GA, USA
Search for more papers by this authorJoseph F. Magliocca
Department of Surgery, Division of Liver Transplantation, Emory University, Atlanta, GA, USA
Search for more papers by this authorRene Romero
Department of Pediatrics, Division of Pediatric Hematology Oncology (Aflac Cancer and Blood Disorders Center), Emory University, Atlanta, GA, USA
Department of Pediatrics, Division of Pediatric Gastroenterology, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA
Search for more papers by this authorCorresponding Author
Sarah Tehseen
Department of Pediatrics, Division of Pediatric Hematology Oncology (Aflac Cancer and Blood Disorders Center), Emory University, Atlanta, GA, USA
Department of Pediatrics, Division of Pediatric Gastroenterology, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA
Correspondence
Sarah Tehseen, Department of Pediatrics, Division of Pediatric Hematology Oncology (Aflac Cancer and Blood Disorders Center), Emory University, Atlanta, GA, USA
Email: [email protected]
Search for more papers by this authorLouis Rapkin
Department of Pediatrics, Division of Pediatric Hematology Oncology (Aflac Cancer and Blood Disorders Center), Emory University, Atlanta, GA, USA
Department of Pediatrics, Division of Pediatric Gastroenterology, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA
Search for more papers by this authorErwin Schemankewitz
Department of Pathology, Children's Healthcare of Atlanta, Atlanta, GA, USA
Search for more papers by this authorJoseph F. Magliocca
Department of Surgery, Division of Liver Transplantation, Emory University, Atlanta, GA, USA
Search for more papers by this authorRene Romero
Department of Pediatrics, Division of Pediatric Hematology Oncology (Aflac Cancer and Blood Disorders Center), Emory University, Atlanta, GA, USA
Department of Pediatrics, Division of Pediatric Gastroenterology, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA
Search for more papers by this authorAbstract
Desmoplastic spindle cell tumors of liver are rare tumors of low malignant potential characterized by well-demarcated nests of spindle and epithelioid cells in a dense desmoplastic stroma. While surgery remains the definitive treatment, there have been reports of tumor recurrence locally and metastasis which respond poorly to chemotherapy. Hepatic transplant has been attempted in cases of recurrence or large size of primary tumor. Long-term follow-up and imaging surveillance are required as these tumors have shown a tendency for recurrence many years after initial therapy.
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