An independent association of prenatal depression with wheezing and anxiety with rhinitis in infancy
Tuck Seng Cheng
KK Women's and Children's Hospital, Singapore City, Singapore
Search for more papers by this authorHelen Chen
KK Women's and Children's Hospital, Singapore City, Singapore
Duke-NUS Graduate Medical School, Singapore City, Singapore
Search for more papers by this authorTheresa Lee
KK Women's and Children's Hospital, Singapore City, Singapore
Duke-NUS Graduate Medical School, Singapore City, Singapore
Search for more papers by this authorOon Hoe Teoh
KK Women's and Children's Hospital, Singapore City, Singapore
Duke-NUS Graduate Medical School, Singapore City, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorLynette P. Shek
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorBee Wah Lee
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorCornelia Chee
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorKeith M. Godfrey
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Search for more papers by this authorPeter D. Gluckman
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore City, Singapore
Liggins Institute, University of Auckland, Auckland, New Zealand
Search for more papers by this authorKenneth Kwek
KK Women's and Children's Hospital, Singapore City, Singapore
Search for more papers by this authorSeang Mei Saw
Saw Swee Hock School of Public Health, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorYap-Seng Chong
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorMichael Meaney
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore City, Singapore
Search for more papers by this authorBirit F. P. Broekman
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore City, Singapore
Search for more papers by this authorOh Moh Chay
KK Women's and Children's Hospital, Singapore City, Singapore
Duke-NUS Graduate Medical School, Singapore City, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorHugo Van Bever
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorCorresponding Author
Anne Goh
KK Women's and Children's Hospital, Singapore City, Singapore
Duke-NUS Graduate Medical School, Singapore City, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Correspondence
Anne Goh, Department of Paediatrics, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore City 229899, Singapore
Tel.: +65 6394 1122
Fax: +65 6291 7923
E-mail: [email protected]
Search for more papers by this authorTuck Seng Cheng
KK Women's and Children's Hospital, Singapore City, Singapore
Search for more papers by this authorHelen Chen
KK Women's and Children's Hospital, Singapore City, Singapore
Duke-NUS Graduate Medical School, Singapore City, Singapore
Search for more papers by this authorTheresa Lee
KK Women's and Children's Hospital, Singapore City, Singapore
Duke-NUS Graduate Medical School, Singapore City, Singapore
Search for more papers by this authorOon Hoe Teoh
KK Women's and Children's Hospital, Singapore City, Singapore
Duke-NUS Graduate Medical School, Singapore City, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorLynette P. Shek
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorBee Wah Lee
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorCornelia Chee
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorKeith M. Godfrey
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Search for more papers by this authorPeter D. Gluckman
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore City, Singapore
Liggins Institute, University of Auckland, Auckland, New Zealand
Search for more papers by this authorKenneth Kwek
KK Women's and Children's Hospital, Singapore City, Singapore
Search for more papers by this authorSeang Mei Saw
Saw Swee Hock School of Public Health, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorYap-Seng Chong
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorMichael Meaney
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore City, Singapore
Search for more papers by this authorBirit F. P. Broekman
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore City, Singapore
Search for more papers by this authorOh Moh Chay
KK Women's and Children's Hospital, Singapore City, Singapore
Duke-NUS Graduate Medical School, Singapore City, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorHugo Van Bever
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Search for more papers by this authorCorresponding Author
Anne Goh
KK Women's and Children's Hospital, Singapore City, Singapore
Duke-NUS Graduate Medical School, Singapore City, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Correspondence
Anne Goh, Department of Paediatrics, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore City 229899, Singapore
Tel.: +65 6394 1122
Fax: +65 6291 7923
E-mail: [email protected]
Search for more papers by this authorAbstract
Background
Different maternal psychological states during pregnancy have been associated with wheeze–rhinitis–eczema symptoms in children. However, previous studies were limited and it was unclear whether the type of prenatal psychological state was associated with a particular symptom. We examined the association of maternal depression and anxiety during pregnancy with wheeze–rhinitis–eczema symptoms in infancy.
Methods
In a longitudinal birth cohort (GUSTO) of 1152 mother–child pairs, wheeze–rhinitis–eczema symptoms in the infants during the first year of life were collected by parental report. Maternal depressive and anxiety symptoms were assessed at 26 weeks of gestation using the Edinburgh Postnatal Depression Scale (EPDS) and State Trait Anxiety Inventory (STAI). Logistic regression analyses were performed with adjustment for potential confounders.
Results
An increased risk of wheezing was found in infants of pregnant women with probable depression (EPDS ≥ 15) [odds ratio (OR) = 1.85 (95% confidence interval (CI) 1.10–3.12)], and an increased risk of rhinitis was associated with maternal anxiety [STAI state ≥ 41: OR = 1.42 (95% CI 1.04–1.93); STAI trait ≥ 43: OR = 1.38 (95% CI 1.01–1.88)]. After adjusting for known risk factors for the development of allergic disease, these associations remained significant [EPDS ≥ 15: adjusted OR = 2.09 (95% CI 1.05–4.19); STAI state ≥ 41: adjusted OR = 1.82 (95% CI 1.17–2.82); STAI trait ≥ 43: adjusted OR = 1.70 (95% CI 1.10–2.61)]. However, maternal psychological states were not associated with infantile eczema.
Conclusion
This study suggests that there may be an independent effect of prenatal depression on wheezing and anxiety on rhinitis in infancy.
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